International Trends in the Incidence of Testicular Cancer: Lessons from 35 Years and 41 Countries.
International Trends in the Incidence of Testicular Cancer: Lessons from 35 Years and 41 Countries.
复制标题
DOI：
10.1016/j.eururo.2019.07.002
复制
发表时间：
2019-11
期刊：
影响因子：
23.4
通讯作者：
McGlynn KA
中科院分区：
文献类型：
--
作者：
Gurney JK;Florio AA;Znaor A;Ferlay J;Laversanne M;Sarfati D;Bray F;McGlynn KA
至少自世纪中期以来，睾丸癌（TC）的发病率在许多国家一直在增加，但没有明确的解释。研究不同国家和时间的不同趋势为理解TC的原因提供了线索。我们提供了来自41个国家的发病率数据，并评估了1978年至2012年35年期间的发病率趋势。分析了来自五大洲癌症发病率（CI5）、CI5plus和NORDCAN数据库的癌症登记数据。计算睾丸癌的总体和组织学类型的标准化率。使用自然对数转换率的联合点回归模型计算发病率的平均年百分比变化（AAPC）。采用同期队列模型研究出生队列对发病率的影响。虽然睾丸癌发病率最高的地区仍然是北方，但发病率较高和较低地区之间的差距正在缩小。2000年期间的队列建模发现，丹麦和英国最近的队列中的风险趋于平缓，美国的风险稳步增加（特别是对于哥伦比亚），而哥斯达黎加，克罗地亚和斯洛伐克最近的队列中的风险增加。低发病率国家和高发病率国家之间的差距正在缩小，原因是前者有所增加，后者趋于稳定。了解国家之间和国家内部发病率的这些和其他差异的原因可能有助于我们进一步了解这种癌症的病因。我们研究了不同国家睾丸癌的发病率。发病率一直在上升，尽管高发病率国家的发病率似乎正在放缓，而低发病率国家的发病率正在迎头赶上。这些趋势可能有助于我们了解一般导致睾丸癌的原因。
Incidence rates of testicular cancer (TC) have been increasing in many countries since at least the mid-20th century without clear explanation. Examining the varying trends across countries and time provides clues to understanding the causes of TC. We have presented incidence data from 41 countries and evaluated incidence trends for the 35-year period from 1978 to 2012. Cancer registry data from Cancer Incidence in Five Continents (CI5) Volumes V-XI, CI5plus, and the NORDCAN database were analyzed. Age-standardised rates of testicular cancer overall and by histologic type were calculated. A joinpoint regression model of the natural log-transformed rates was used to calculate the average annual percent change (AAPC) in incidence. Age-period-cohort modeling was used to examine the effect of birth cohort on rates. While the highest incidence of testicular cancer remains in Northern Europe, the gap is closing between higher- and lower-incidence regions. Age-period-cohort modeling found a flattening of risk among recent cohorts in Denmark and the United Kingdom, a steady increase in risk in the United States (particularly for seminomas), and an increase in risk among more recent cohorts in Costa Rica, Croatia and Slovakia. The gap between low and high incidence countries is closing due to increases in the former and stabilisation in the latter. Understanding the causes of these and other differences in incidence rates between, and within, countries may help to further our understanding of the aetiology of this cancer. We examined the rates of testicular cancer in different countries over time. Rates have been increasing, although rates in high incidence countries seem to be slowing down, while rates in low incidence countries are catching up. These trends might help us understand what is causing testicular cancer in general.
登录
查看更多内容
影响因子：
6.4
作者：
Bray, F.;Ferlay, J.;Forman, D.
通讯作者：
Forman, D.
影响因子：
3.1
作者：
Fosså, SD
通讯作者：
Fosså, SD
影响因子：
4.5
作者：
Trabert B;Chen J;Devesa SS;Bray F;McGlynn KA
通讯作者：
McGlynn KA
影响因子：
8.8
作者：
Coupland, CAC;Chilvers, CED;Davey, G;Pike, MC;Oliver, RTD;Forman, D
通讯作者：
Forman, D
影响因子：
--
作者：
Puehse, Gerald;Wachsmuth, Julia Urte;Kliesch, Sabine
通讯作者：
Kliesch, Sabine