Risk factors for testicular germ cell tumours by histological tumour type. United Kingdom Testicular Cancer Study Group.
Risk factors for testicular germ cell tumours by histological tumour type. United Kingdom Testicular Cancer Study Group.
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DOI：
10.1038/sj.bjc.6690611
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发表时间：
1999-08
影响因子：
8.8
通讯作者：
Forman, D
中科院分区：
文献类型：
--
作者：
Coupland, CAC;Chilvers, CED;Davey, G;Pike, MC;Oliver, RTD;Forman, D
睾丸生殖细胞肿瘤有两种主要的组织学类型，它们可能具有不同的风险因素。一些作者分析了组织学组的潜在风险因素，但几乎没有一致的差异。在本文中，我们使用英国睾丸癌病例对照研究的数据，研究单纯性睾丸癌和其他肿瘤的风险因素。794例病例被纳入研究，每个病例都有一个匹配的对照组; 400例为纯睾丸腺瘤肿瘤，394例为其他睾丸肿瘤。与隐睾相关的腺瘤的风险略高于其他肿瘤（比值比为5.3比3.0）。当按诊断时的中位年龄分开时，32岁及以上男性的这种差异（比值比为11.9比5.1）大于年轻男性（3.0比2.5）。在非腺瘤组中，与睾丸或腹股沟损伤相关的风险较高，性传播疾病史的风险也较高。对于其他组织学类型的肿瘤，青春期晚的保护作用更为显著。在参加体育运动方面也发现了一些差异。虽然检测到的一些差异可能是偶然出现的，但许多其他研究已经确定了隐睾和单纯性睾丸腺瘤之间的更强关联，这可能反映了病因学上的真正差异。© 1999癌症研究运动
There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using data from the United Kingdom case control study of testicular cancer. Seven hundred and ninety-four cases were included in the study, each with a matched control; 400 cases had pure seminoma tumours, and 394 had other testicular tumours. The risk of seminoma associated with undescended testis was slightly higher than that for other tumours (odds ratio of 5.3 compared with 3.0). When split at the median age at diagnosis, this difference was greater in men aged 32 and over (odds ratio of 11.9 compared with 5.1) than in the younger men (3.0 compared with 2.5). Risks associated with testicular or groin injuries were higher in the non-seminoma group, as was the risk for a history of sexually transmitted disease. The protective effect of a late puberty was more marked for tumours of other histologies. Some differences were also detected for participation in sports. Whilst some of the differences detected may have arisen by chance, the stronger association between undescended testis and pure seminoma has been identified by a number of other studies and may reflect a genuine difference in aetiology. © 1999 Cancer Research Campaign
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影响因子：
5
作者：
MOSS, AR;OSMOND, D;GURGIN, V
通讯作者：
GURGIN, V
影响因子：
8.8
作者：
Coldman, A J;Elwood, J M;Gallagher, R P
通讯作者：
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作者：
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通讯作者：
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影响因子：
7.7
作者：
HAYES, RB;BROWN, LM;JAVADPOUR, N
通讯作者：
JAVADPOUR, N