Molecular pathogenesis of the cell surface proteins and lipids from Treponema denticola.
Molecular pathogenesis of the cell surface proteins and lipids from Treponema denticola.
复制标题
齿垢密螺旋体细胞表面蛋白和脂质的分子发病机制。
作者：
K. Ishihara;K. Okuda
齿垢密螺旋体是人类牙周病的主要病原体，常从口腔中分离。分子分析的最新进展阐明了这种微生物的表面结构及其致病因子的特征。外鞘的结构分析显示T。有一种新型的外膜脂质。电子显微镜分析表明，主要外鞘蛋白的有限暴露。蛋白酶缺陷突变体揭示了蛋白酶在外鞘物质的组织和T。齿垢致病性对T.牙周病中的齿垢逐渐被阐明，并进行了审查。
Treponema denticola, frequently isolated from the human oral cavity, is thought to be a major pathogen of human periodontal disease. Recent developments in molecular analysis have clarified the surface structure of this microorganism and the characteristics of its pathogenic factors. Structural analysis of the outer sheath showed T. denticola to have a new type of outer membrane lipid. Limited exposure of the major outer sheath protein is suggested by electron-microscopic analysis. A protease-deficient mutant has revealed the roles of the protease in the organization of the outer sheath material and in T. denticola pathogenicity. The surface features that contribute to the pathogenicity of T. denticola in periodontal disease are gradually being elucidated, and are reviewed.
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影响因子：
3.8
作者：
J. Ebersole;L. Kesavalu;S. Schneider;R. Machen;S. Holt
通讯作者：
J. Ebersole;L. Kesavalu;S. Schneider;R. Machen;S. Holt
DOI：
10.1902/annals.1998.3.1.233
发表时间：
1998-07-01
期刊：
Annals of periodontology
影响因子：
--
作者：
Offenbacher, S;Jared, H L;Beck, J D
通讯作者：
Beck, J D
影响因子：
56.9
作者：
Fraser, CM;Norris, SJ;Venter, JC
通讯作者：
Venter, JC
口腔螺旋体抑制人类淋巴细胞反应：单核细胞依赖性现象。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Shenker,BJ;Listgarten,MA;Taichman,NS
通讯作者：
Taichman,NS
影响因子：
6.7
作者：
Socransky, SS;Haffajee, AD;Kent, RL
通讯作者：
Kent, RL