Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.
Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.
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婴儿早期期间的低肥胖与患登革热出血热的风险低有关：初步模型。
DOI：
10.1371/journal.pone.0088944
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Capeding RZ
中科院分区：
文献类型：
--
作者：
Libraty DH;Zhang L;Woda M;Giaya K;Kathivu CL;Acosta LP;Tallo V;Segubre-Mercado E;Bautista A;Obcena A;Brion JD;Capeding RZ
Dengue virus (DENV) infections range from asymptomatic or mild illness to a severe and potentially life threatening disease, dengue hemorrhagic fever (DHF). DHF occurs in primary DENV infections during early infancy. A prospective clinical study of DENV infections during infancy was conducted in San Pablo, Philippines. We found that infants who developed DHF with a primary DENV infection had higher WHO weight-for-age z scores before and at the time of infection compared to infants with primary DENV infections who did not develop DHF. In addition, TLR 7/8-stimulated tumor necrosis factor-α (TNF-α) production from myeloid-derived cells was higher among well-nourished infants. Leptin augmented TLR 7/8-mediated TNF-α production in monocytes and decreased intracellular cAMP levels. Circulating leptin levels were elevated during early infancy and correlated with WHO weight-for-age z scores. Our data support a plausible hypothesis as to why well-nourished infants are at risk for developing DHF with their first DENV infection.
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