Expression of lymphocyte perforin in the mouse uterus during pregnancy.
Expression of lymphocyte perforin in the mouse uterus during pregnancy.
复制标题
妊娠期小鼠子宫淋巴细胞穿孔素的表达。
作者：
Li Mou Zheng;Chau‐Ching Liu;D. Ojcius;J. Young
用原位杂交和免疫荧光技术研究了淋巴细胞孔形成蛋白（穿孔素）在妊娠小鼠子宫中的表达。表达穿孔素mRNA的细胞早在妊娠第5天就被检测到，而穿孔素蛋白则在妊娠1 - 2天后才被检测到。尽管表达穿孔素mRNA和穿孔素蛋白的细胞数量随后随时间而变化，但从植入当天直到分娩一直观察到它们。在妊娠中期的某个时候观察到最高水平的mRNA表达。妊娠期间子宫腺中这种溶细胞蛋白的高丰度及其表达的时程因此表明，GMG穿孔素的表达受到子宫的严格调控，可能是生殖调控，并且GMG细胞穿孔素在妊娠的正常完成中起着重要作用。
In situ hybridization and immunofluorescence were used to study the expression of a lymphocyte pore-forming protein (perforin) in the uterus of pregnant mice. Cells expressing perforin mRNA were detected as early as gestation day 5, whereas perforin protein was detected one or two days later. Although the number of cells expressing both perforin mRNA and perforin protein varied subsequently with time, they were consistently observed from the day of implantation until parturition. The highest levels of mRNA expression were observed sometime during midgestation. The high abundance of this cytolytic protein in the metrial gland during pregnancy and the time course of its expression thus suggest that GMG perforin expression is tightly regulated, probably hormonally, by the uterus, and that GMG cell perforin plays an important role in the normal completion of pregnancy.
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DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Parr,EL;Young,LH;Parr,MB;Young,JD
通讯作者：
Young,JD
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作者：
Young,JD
通讯作者：
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病毒感染期间自然杀伤细胞体内表达穿孔素。
DOI：
--
发表时间：
1990
期刊：
The American journal of pathology
影响因子：
--
作者：
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通讯作者：
Young,JD
影响因子：
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作者：
L. Young;L. Peterson;L. Wicker;P. Persechini;J. D. Young
通讯作者：
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影响因子：
3.6
作者：
Parr,EL;Parr,MB;Young,JD
通讯作者：
Young,JD