European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment.

European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment.
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DOI:
10.1007/s00787-011-0163-7
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发表时间:
2011-04
影响因子:
6.4
通讯作者:
Hoekstra, Pieter J.
Hoekstra, Pieter J.
中科院分区:
医学2区
文献类型:
--
作者:
Roessner, Veit;Plessen, Kerstin J.;Rothenberger, Aribert;Ludolph, Andrea G.;Rizzo, Renata;Skov, Liselotte;Strand, Gerd;Stern, Jeremy S.;Termine, Cristiano;Hoekstra, Pieter J.

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为了制定欧洲抽动秽语综合征 (TS) 药物治疗指南,欧洲抽动秽语综合征研究学会 (ESSTS) 的一个工作组对现有文献进行了彻底筛选和广泛讨论。尽管关于 TS 药物治疗的研究多于行为治疗选择的研究,但只有有限数量的研究符合严格的质量标准。因此,我们设计了一个两阶段的方法。首先,我们通过报告该领域现有 Cochrane 综述的结果来提供最高水平的证据。随后,我们通过 MEDLINE、PubMed 和 EMBASE 搜索所有记录 1970 年至 2010 年 11 月间记录 TS 和其他抽动障碍药物治疗效果的研究,首次全面概述了 TS 药物治疗方案的所有报告。我们总结了欧洲 TS 药物治疗方案的当前共识,以指导临床医生的日常实践。然而,这一总结只是一个对临床有帮助但证据不足的指南,主要由专家经验和意见驱动,因为严格的实验研究很少。
To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS) the available literature was thoroughly screened and extensively discussed by a working group of the European Society for the Study of Tourette syndrome (ESSTS). Although there are many more studies on pharmacotherapy of TS than on behavioral treatment options, only a limited number of studies meets rigorous quality criteria. Therefore, we have devised a two-stage approach. First, we present the highest level of evidence by reporting the findings of existing Cochrane reviews in this field. Subsequently, we provide the first comprehensive overview of all reports on pharmacological treatment options for TS through a MEDLINE, PubMed, and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010. We present a summary of the current consensus on pharmacological treatment options for TS in Europe to guide the clinician in daily practice. This summary is, however, rather a status quo of a clinically helpful but merely low evidence guideline, mainly driven by expert experience and opinion, since rigorous experimental studies are scarce.
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