Hierarchical organization of bone in three dimensions: A twist of twists.
Hierarchical organization of bone in three dimensions: A twist of twists.
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DOI：
10.1016/j.yjsbx.2021.100057
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发表时间：
2022
影响因子：
--
通讯作者：
Reznikov N
中科院分区：
文献类型：
--
作者：
Buss DJ;Kröger R;McKee MD;Reznikov N
骨结构元素的扭曲可以在多个尺度上发现。3D成像和分析支持了Pettigrew和Thompson的原始观察。扭曲形式的自相似性是骨结构的标志。考虑骨的扭曲/螺旋可能会增强对功能的理解。骨的结构层次-在多个尺度和三维（3D）中观察-对其机械性能至关重要。骨的矿化细胞外基质主要由碳酸盐取代的羟基磷灰石、I型胶原原纤维、水和非胶原有机成分（主要是蛋白质和小蛋白聚糖）组成，主要是这些无机和有机成分在每个长度尺度上的三维排列赋予骨独特的力学性能。从单个矿化胶原纤维的水平到整个骨骼的水平，这篇图像综述集中在最近对这些尺度上的骨骼体积成像研究上，并重新强调了詹姆斯·贝尔·佩蒂格鲁和达西·汤普森的原创作品，他们首次在《自然》中描述了螺旋结构的普遍性。在这里，我们说明并讨论了骨骼中扭曲、弯曲、正弦、盘绕、螺旋和编织的图案在其12个层次中的至少9个层次上的无所不在-这是一项可视化工作，直到最近3D成像技术的进步才成为可能（以前的2D成像不能提供这些信息）。从这个角度来看，我们假设在每个骨层次上发生的扭曲基序与功能增强直接相关，而不仅仅是一种能量有利的方式来组装矿化基质成分。我们建议在不同的尺度上仔细考虑骨骼和骨骼的扭曲，并将增强我们对骨骼结构-功能关系的理解。
Twisting of structural elements of bone can be found across multiple scales. 3D imaging and analysis supports original observations by Pettigrew and Thompson. Self-similarity in the form of the twist is a hallmark of bone structure. Consideration of twisting/spiraling in bone may enhance understanding of function. Structural hierarchy of bone – observed across multiple scales and in three dimensions (3D) – is essential to its mechanical performance. While the mineralized extracellular matrix of bone consists predominantly of carbonate-substituted hydroxyapatite, type I collagen fibrils, water, and noncollagenous organic constituents (mainly proteins and small proteoglycans), it is largely the 3D arrangement of these inorganic and organic constituents at each length scale that endow bone with its exceptional mechanical properties. Focusing on recent volumetric imaging studies of bone at each of these scales – from the level of individual mineralized collagen fibrils to that of whole bones – this graphical review builds upon and re-emphasizes the original work of James Bell Pettigrew and D’Arcy Thompson who first described the ubiquity of spiral structure in Nature. Here we illustrate and discuss the omnipresence of twisted, curved, sinusoidal, coiled, spiraling, and braided motifs in bone in at least nine of its twelve hierarchical levels – a visualization undertaking that has not been possible until recently with advances in 3D imaging technologies (previous 2D imaging does not provide this information). From this perspective, we hypothesize that the twisting motif occurring across each hierarchical level of bone is directly linked to enhancement of function, rather than being simply an energetically favorable way to assemble mineralized matrix components. We propose that attentive consideration of twists in bone and the skeleton at different scales will likely develop, and will enhance our understanding of structure–function relationships in bone.
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影响因子：
10
作者：
Ayoubi, Mahdi;van Tol, Alexander F.;Fratzl, Peter
通讯作者：
Fratzl, Peter
DOI：
10.1098/rspb.1979.0086
发表时间：
1979-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GOULD, SJ;LEWONTIN, RC
通讯作者：
LEWONTIN, RC
影响因子：
56.9
作者：
BELLA, J;EATON, M;BERMAN, HM
通讯作者：
BERMAN, HM
影响因子：
3
作者：
Prockop, DJ;Fertala, A
通讯作者：
Fertala, A
DOI：
10.1142/s1793048011001245
发表时间：
2011-06-01
期刊：
Biophysical Reviews and Letters
影响因子：
--
作者：
Charvolin, Jean;Sadoc, Jean-Francois
通讯作者：
Sadoc, Jean-Francois