The effects of the mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial.
The effects of the mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial.
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DOI：
10.1371/journal.pone.0100084
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Estruch R
中科院分区：
文献类型：
--
作者：
Casas R;Sacanella E;Urpí-Sardà M;Chiva-Blanch G;Ros E;Martínez-González MA;Covas MI;Rosa Ma Lamuela-Raventos;Salas-Salvadó J;Fiol M;Arós F;Estruch R
坚持地中海饮食（MD）与降低心血管疾病的发病率和死亡率有关。然而，MD如何发挥其作用尚不完全清楚。在PREDIMED（Mediterránea膳食补充剂）研究的一个子队列中，评估两种强化MD与低脂饮食相比对动脉粥样硬化和斑块易损性相关炎症生物标志物的12个月影响。共有164名心血管疾病高风险参与者被随机分为三个饮食组：MD补充50 mL/d的特级初榨橄榄油（MD+EVOO）或30 g/d的坚果（MD+Nuts）和低脂饮食。干预12个月后，测量经典心血管危险因素、动脉粥样硬化炎性生物标志物和斑块易损性的变化。与低脂饮食组的参与者相比，接受MD+EVOO和MD+Nuts的参与者显示收缩压（6 mmHg）和舒张压（3 mmHg）降低幅度更大（P = 0.02;两者），以及LDL胆固醇分别降低10%和8%（P = 0.04）。 与低脂饮食患者相比，MD+Nuts组患者单核细胞表面CD 40表达显著降低34%（P = 0.03）。 此外，与低脂饮食组相比，MD+EVOO组和MD+Nuts组中与斑块不稳定性相关的炎症生物标志物（如C-反应蛋白和白细胞介素-6）分别降低了45%和35%以及95%和90%（P<0.05;均）。同样，与低脂饮食组相比，MD+EVOO组中的sICAM和P-选择素也分别降低了50%和27%（P = 0.04），MD+Nuts组中的P-选择素降低了19%（P = 0.04）。 坚持MD与动脉粥样硬化斑块稳定性的血清标志物的增加有关，这可以解释，至少部分地，MD对缺血性心脏病的保护作用。 www.controlled-trials.com www.example.com
Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevención con Dieta Mediterránea) study. A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6mmHg) and diastolic (3mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and P-selectin were also reduced by 50% and 27%, respectively in the MD+EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease. www.controlled-trials.com ISRCTN35739639
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