Altered expression of microRNA-92b-3p predicts survival outcomes of patients with prostate cancer and functions as an oncogene in tumor progression.
Altered expression of microRNA-92b-3p predicts survival outcomes of patients with prostate cancer and functions as an oncogene in tumor progression.
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MicroRNA-92B-3P的表达改变预测了前列腺癌患者的生存结果，并在肿瘤进展中起癌基因的作用。
DOI：
10.3892/ol.2020.12265
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发表时间：
2021-01
期刊：
影响因子：
2.9
通讯作者：
Liu W
中科院分区：
文献类型：
--
作者：
Wang G;Cheng B;Jia R;Tan B;Liu W
近年来，前列腺癌（PCa）的全球发病率一直在增加。同时，一些研究表明，恶性肿瘤，如肺癌和胃癌与PCa，和microRNAs（miRNAs）之间的关联。本研究旨在评估miR-92 b-3 p在PCa患者中的预后价值，并进一步研究miR-92 b-3 p的生物学功能。采用实时荧光定量聚合酶链反应（RT-PCR）检测miR-92 b-3 p在PCa组织和细胞系中的表达，并与正常组织和细胞进行比较。Kaplan-Meier法分析PCa患者的总生存率。使用考克斯回归分析来验证miR-92 b-3 p的预后价值。使用细胞实验研究miR-92 b-3 p的生物学功能。本研究的结果显示，与正常组织和细胞相比，miR-92 b-3 p在PCa组织和细胞中的表达上调。miR-92 b-3 p的过表达与PCa的远处转移状态和肿瘤-淋巴结-转移分期显著相关，并预示PCa的不良预后。此外，细胞实验结果表明，miR-92 b-3 p在PCa细胞中过表达可促进细胞增殖、迁移和侵袭。目前的研究表明，miR-92 b-3 p的过表达预测PCa患者的预后不良。miR-92 b-3 p表达降低可抑制PCa细胞的增殖、迁移和侵袭，提示miR-92 b-3 p可能作为癌基因发挥作用，成为PCa治疗的新靶点。
The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with PCa and further investigate the biological function of miR-92b-3p. Real-time quantitative polymerase chain reaction was used to estimate the expression of miR-92b-3p in PCa tissues and cell lines compared with normal tissues and cells. Kaplan-Meier method was used to analyze the overall survival rate of patients with PCa. A Cox regression analysis was used to verify the prognostic value of miR-92b-3p. The biological function of miR-92b-3p was investigated using cell experiments. The findings of the present study revealed the upregulated expression of miR-92b-3p in PCa tissues and cells compared with normal tissues and cells. The overexpression of miR-92b-3p was significantly associated with the distant metastasis status and Tumor-Node-Metastasis stage of patients with PCa and predicted poor prognosis of PCa. In addition, the cell experiment results indicated that miR-92b-3p overexpression in PCa cells promoted cell proliferation, migration and invasion. The present study revealed that the overexpression of miR-92b-3p predicted poor prognosis in patients with PCa. Decreased expression of miR-92b-3p can suppress PCa cell proliferation, migration and invasion, which indicated that miR-92b-3p may function as an oncogene and serve as a novel therapeutic target for PCa.
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影响因子：
3.9
作者：
Krebs, Markus;Solimando, Antonio Giovanni;Kneitz, Burkhard
通讯作者：
Kneitz, Burkhard
影响因子：
3
作者：
Gong, M.;Chen, C.;Song, M.
通讯作者：
Song, M.
miRNA在癌细胞和肿瘤微环境中的管制。
影响因子：
28.2
作者：
Rupaimoole R;Calin GA;Lopez-Berestein G;Sood AK
通讯作者：
Sood AK
影响因子：
254.7
作者：
Torre, Lindsey A.;Bray, Freddie;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
4
作者：
Ma, Hui;Wang, Li-Yong;Kong, Lu
通讯作者：
Kong, Lu