Fluorescein angiographic observations of peripheral retinal vessel growth in infants after intravitreal injection of bevacizumab as sole therapy for zone I and posterior zone II retinopathy of prematurity.
Fluorescein angiographic observations of peripheral retinal vessel growth in infants after intravitreal injection of bevacizumab as sole therapy for zone I and posterior zone II retinopathy of prematurity.
复制标题
DOI：
10.1136/bjophthalmol-2013-304109
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
McMenamin PG
中科院分区：
文献类型：
--
作者：
Tahija SG;Hersetyati R;Lam GC;Kusaka S;McMenamin PG
使用荧光素血管造影（FA）数字记录评价接受玻璃体内贝伐珠单抗（IVB）作为I区和后II区早产儿视网膜病变（ROP）唯一治疗的婴儿的外周视网膜血管形成。对2007年8月至2012年11月期间接受玻璃体内贝伐珠单抗注射作为I区和后II区ROP唯一治疗的10例新生儿（20只眼）的病历、RetCam眼底图像和RetCam荧光素血管造影视频进行了回顾性评价。所有患眼在IVB注射后均通过RetCam彩色眼底照片记录了后部疾病的初始消退。使用从锯齿缘到血管末端的2个椎间盘直径的距离作为儿童允许的无血管视网膜的上限，这些婴儿的FA表明，20只眼睛中有11只没有实现正常的视网膜血管形成。 虽然贝伐单抗似乎有效地解决了I区和后II区ROP，并允许周边视网膜血管生长，但在我们的20只眼系列中，有一半患者未实现完全正常的周边视网膜血管形成。
To evaluate vascularisation of the peripheral retina using fluorescein angiography (FA) digital recordings of infants who had been treated with intravitreal bevacizumab (IVB) as sole therapy for zone I and posterior zone II retinopathy of prematurity (ROP). A retrospective evaluation was performed of medical records, RetCam fundus images and RetCam fluorescein angiogram videos of 10 neonates (20 eyes) who received intravitreal bevacizumab injections as the only treatment for zone I and posterior zone II ROP between August 2007 and November 2012. All eyes had initial resolution of posterior disease after IVB injection as documented by RetCam colour fundus photographs. Using a distance of 2 disc diameters from the ora serrata to vascular termini as the upper limit of allowable avascular retina in children, the FA of these infants demonstrated that 11 of 20 eyes had not achieved normal retinal vascularisation. Although bevacizumab appears effective in bringing resolution of zone I and posterior zone II ROP and allowing growth of peripheral retinal vessels, in our series of 20 eyes, complete normal peripheral retinal vascularisation was not achieved in half of the patients.
登录
查看更多内容
影响因子：
--
作者：
Travassos, Antonio;Teixeira, Susana;do Ceu Machado, Maria
通讯作者：
do Ceu Machado, Maria
影响因子：
4.2
作者：
Azuma, Noriyuki;Ishikawa, Kaoru;Nishina, Sachiko
通讯作者：
Nishina, Sachiko
影响因子：
2.3
作者：
Harder, Bjoern C.;von Baltz, Stefan;Schlichtenbrede, Frank C.
通讯作者：
Schlichtenbrede, Frank C.
影响因子：
13.7
作者：
Kaiser, RS;Trese, MT;Cox, MS
通讯作者：
Cox, MS
影响因子：
1.6
作者：
Katz, X;Kychenthal, A;Dorta, P
通讯作者：
Dorta, P