The Hypothalamic Preoptic Area and Body Weight Control.

The Hypothalamic Preoptic Area and Body Weight Control.
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DOI:
10.1159/000479875
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发表时间:
2018
期刊:
影响因子:
4.1
通讯作者:
Münzberg H
Münzberg H
中科院分区:
医学2区
文献类型:
--
作者:
Yu S;François M;Huesing C;Münzberg H

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下丘脑的视前区(POA)参与了许多生理和行为过程,这要归功于它与许多大脑区域的相互联系和对各种体液因素的反应能力。POA的一个主要功能是管理体温的动态平衡,例如响应环境温度的变化,这在一定程度上是通过控制棕色脂肪组织的产热来实现的。POA还重要地参与调节食物摄入量以应对温度变化,从而使其与体重动态平衡和肥胖研究相关。POA在体重控制中的作用还没有得到很好的探索,更好地了解POA回路及其与调节能量动态平衡的经典下丘脑回路的整合,有望为肥胖和合并症的科学基础和治疗提供新的机会。
The preoptic area (POA) of the hypothalamus is involved in many physiological and behavioral processes thanks to its interconnections to many brain areas and ability to respond to diverse humoral factors. One main function of the POA is to manage body temperature homeostasis, e.g. in response to ambient temperature change, which is achieved in part by controlling brown adipose tissue thermogenesis. The POA is also importantly involved in modulating food intake in response to temperature change, thus making it relevant for body weight homeostasis and obesity research. POA function in body weight control is highly unexplored, and a better understanding of POA circuits and their integration into classic hypothalamic circuits that regulate energy homeostasis is expected to provide new opportunities for the scientific basis and treatment of obesity and comorbidities.
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