Pathological angiogenesis and inflammation in tissues.
Pathological angiogenesis and inflammation in tissues.
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DOI：
10.1007/s12272-020-01287-2
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发表时间：
2021-01
影响因子：
6.7
通讯作者：
Lee YM
中科院分区：
文献类型：
--
作者：
Jeong JH;Ojha U;Lee YM
血管生成在器官和肿瘤生长中的作用已被广泛认识。血管-器官相互作用是一个关键的机制和概念，使我们能够理解所有生物现象和正常生理，这是人类在病理条件下生存所必需的。近年来，血管内皮细胞被归类为一类依赖于病理情况的先天免疫细胞。此外，炎症因子和信号调节因子在暴露于感染或各种应激时被激活，在组织实质细胞、外周免疫细胞、基质细胞和癌细胞的病理功能中起着至关重要的作用。因此，在生理和病理条件下，作为血管微环境或组织微环境的血管-器官相互作用作为一个有趣的研究课题越来越受到人们的欢迎。在这里，我们回顾了血管在正常和癌组织的发病过程中作为微环境稳态的主要因素的贡献。此外，我们认为病理性血管生成的正常化策略可能是包括癌症在内的各种疾病的有希望的治疗靶点。
The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–organ interaction is a key mechanism and a concept that enables an understanding of all biological phenomena and normal physiology that is essential for human survival under pathological conditions. Recently, vascular endothelial cells have been classified as a type of innate immune cells that are dependent on the pathological situations. Moreover, inflammatory cytokines and signaling regulators activated upon exposure to infection or various stresses play crucial roles in the pathological function of parenchymal cells, peripheral immune cells, stromal cells, and cancer cells in tissues. Therefore, vascular–organ interactions as a vascular microenvironment or tissue microenvironment under physiological and pathological conditions are gaining popularity as an interesting research topic. Here, we review vascular contribution as a major factor in microenvironment homeostasis in the pathogenesis of normal as well as cancerous tissues. Furthermore, we suggest that the normalization strategy of pathological angiogenesis could be a promising therapeutic target for various diseases, including cancer.
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