BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.
BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.
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BCCIPβ 通过直接相互作用调节 S7 的核糖体和核糖体外功能
DOI：
10.1093/jmcb/mjx019
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发表时间：
2017-06-01
影响因子：
5.5
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Ba Q;Li X;Huang C;Li J;Fu Y;Chen P;Duan J;Hao M;Zhang Y;Li J;Sun C;Ying H;Song H;Zhang R;Shen Z;Wang H
核糖体蛋白（RPs）的核糖体外功能在肿瘤发生发展中的作用已引起广泛关注。然而，RPs的核糖体和核糖体外功能之间的转换的调节很少报道。在此，我们鉴定了核糖体蛋白S7相互作用伴侣BCCIP β，其调节S7的功能转换。BCCIP β通过N端酸性结构域与S7的中央碱性区域相互作用，调节S7的核糖体外分布。BCCIP β缺陷消除了核糖体的积累，但增强了S7的无核糖体定位。这种易位进一步损害蛋白质合成并引发核糖体应激。因此，BCCIP β缺陷抑制核糖体功能并启动S7的核糖体外功能，导致细胞增殖受限。此外，发现临床相关的S7突变抑制与BCCIP β的相互作用并促进S7的功能转变。总之，BCCIP β作为S7调节剂，有助于调节S7的核糖体和核糖体外功能，并在细胞生长和肿瘤发展中具有意义。
Extraribosomal functions of ribosomal proteins (RPs) have gained much attention for their implications in tumorigenesis and progression. However, the regulations for transition between the ribosomal and extraribosomal functions of RPs are rarely reported. Herein, we identified a ribosomal protein S7-interacting partner, BCCIPβ, which modulates the functional conversion of S7. Through the N-terminal acidic domain, BCCIPβ interacts with the central basic region in S7 and regulates the extraribosomal distribution of S7. BCCIPβ deficiency abrogates the ribosomal accumulation but enhances the ribosome-free location of S7. This translocation further impairs protein synthesis and triggers ribosomal stress. Consequently, BCCIPβ deficiency suppresses the ribosomal function and initiates the extraribosomal function of S7, resulting in restriction of cell proliferation. Moreover, clinically relevant S7 mutations were found to dampen the interaction with BCCIPβ and facilitate the functional transition of S7. In conclusion, BCCIPβ, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development.
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影响因子：
8
作者：
Meng, X.;Fan, J.;Shen, Z.
通讯作者：
Shen, Z.
影响因子：
4.8
作者：
Ono, T;Kitaura, H;Ariga, H
通讯作者：
Ariga, H
影响因子：
14.8
作者：
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影响因子：
11.2
作者：
Huang YY;Dai L;Gaines D;Droz-Rosario R;Lu H;Liu J;Shen Z
通讯作者：
Shen Z
影响因子：
4
作者：
Phillips-Mason, Polly J.;Mourton, Tracy;Major, Denice L.;Brady-Kalnay, Susann M.
通讯作者：
Brady-Kalnay, Susann M.