Genome-wide assessment of gene-by-smoking interactions in COPD.
Genome-wide assessment of gene-by-smoking interactions in COPD.
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DOI：
10.1038/s41598-018-27463-5
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发表时间：
2018-06-18
影响因子：
4.6
通讯作者：
Won S
中科院分区：
文献类型：
--
作者：
Park B;Koo SM;An J;Lee M;Kang HY;Qiao D;Cho MH;Sung J;Silverman EK;Yang HJ;Won S
Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking interactions have been reported. In this report, we evaluated the effects of gene-smoking interactions on lung function using Korea Associated Resource (KARE) data with the spirometric variables—forced expiratory volume in 1 s (FEV1). We found that variations in FEV1 were different among smoking status. Thus, we considered a linear mixed model for association analysis under heteroscedasticity according to smoking status. We found a previously identified locus near SOX9 on chromosome 17 to be the most significant based on a joint test of the main and interaction effects of smoking. Smoking interactions were replicated with Gene-Environment of Interaction and phenotype (GENIE), Multi-Ethnic Study of Atherosclerosis-Lung (MESA-Lung), and COPDGene studies. We found that individuals with minor alleles, rs17765644, rs17178251, rs11870732, and rs4793541, tended to have lower FEV1 values, and lung function decreased much faster with age for smokers. There have been very few reports to replicate a common variant gene-smoking interaction, and our results revealed that statistical models for gene-smoking interaction analyses should be carefully selected.
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影响因子：
10.4
作者：
Imboden M;Kumar A;Curjuric I;Adam M;Thun GA;Haun M;Tsai MY;Pons M;Bettschart R;Turk A;Rochat T;Künzli N;Schindler C;Kronenberg F;Probst-Hensch NM
通讯作者：
Probst-Hensch NM
影响因子：
9.6
作者：
Hankinson, John L.;Kawut, Steven M.;Barr, R. Graham
通讯作者：
Barr, R. Graham
影响因子：
3.7
作者：
Aldrich MC;Kumar R;Colangelo LA;Williams LK;Sen S;Kritchevsky SB;Meibohm B;Galanter J;Hu D;Gignoux CR;Liu Y;Harris TB;Ziv E;Zmuda J;Garcia M;Leak TS;Foreman MG;Smith LJ;Fornage M;Liu K;Burchard EG;Health ABC and CARDIA Studies Groups
通讯作者：
Health ABC and CARDIA Studies Groups
DOI：
10.1164/rccm.201403-0569oc
发表时间：
2014-08-15
影响因子：
24.7
作者：
Castaldi, Peter J.;Cho, Michael H.;Silverman, Edwin K.
通讯作者：
Silverman, Edwin K.
不同的基因与颗粒物质和烟草烟雾相互作用，在影响一般人群的肺功能下降时与烟雾烟相互作用。
影响因子：
3.7
作者：
Curjuric I;Imboden M;Nadif R;Kumar A;Schindler C;Haun M;Kronenberg F;Künzli N;Phuleria H;Postma DS;Russi EW;Rochat T;Demenais F;Probst-Hensch NM
通讯作者：
Probst-Hensch NM