Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.
Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.
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DOI：
10.1371/journal.pcbi.1010942
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发表时间：
2023-03
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在整个大脑中发现了慢速和快速振荡之间的相位耦合（PAC），其神经元的起源仍然不清楚。在这里使用海马微电路的数据驱动的模型，在这里产生PAC。自然而然地从涉及抑制性和兴奋性神经元种群的单个反馈机制中出现，该机制相互作用以产生较高频率γ的theta频率周期性爆发。 OLM和PVBC细胞的调节作用，复发性连通性和短期突触可塑性。可检验的预测，人口缓慢振荡的产生需要快速的预测，没有它就不能发生。
振荡是大脑作战的突出和无处不在的特征。由于海马中的theta（3-8 Hz）和伽马（25-100 Hz），因此发现这些振荡是耦合的这种“相位振幅耦合”本身的强度取决于动物的认知状态和持续的行为，因此，尽管这种现象的重要性，其生物物理起源及其原因，但仍被认为具有重要的功能。在这里，使用数据驱动的海马CA1的计算模型，整个大脑区域和物种的普遍存在仍然不清楚。基本的微电路如何自主产生theta和gamma，这是相结合的。
Phase amplitude coupling (PAC) between slow and fast oscillations is found throughout the brain and plays important functional roles. Its neural origin remains unclear. Experimental findings are often puzzling and sometimes contradictory. Most computational models rely on pairs of pacemaker neurons or neural populations tuned at different frequencies to produce PAC. Here, using a data-driven model of a hippocampal microcircuit, we demonstrate that PAC can naturally emerge from a single feedback mechanism involving an inhibitory and excitatory neuron population, which interplay to generate theta frequency periodic bursts of higher frequency gamma. The model suggests the conditions under which a CA1 microcircuit can operate to elicit theta-gamma PAC, and highlights the modulatory role of OLM and PVBC cells, recurrent connectivity, and short term synaptic plasticity. Surprisingly, the results suggest the experimentally testable prediction that the generation of the slow population oscillation requires the fast one and cannot occur without it. Oscillations are a prominent and ubiquitous feature of brain operations. They are found across multiple different animal species and with a variety of recording techniques from small-scale microelectrodes up to large-scale EEG and fMRI. Oscillations appear in a range of discrete frequencies, such as theta (3-8 Hz) and gamma (25-100 Hz) in the hippocampus. Notably, these oscillations are found to be coupled whereby the phase of the slower oscillation modulates the amplitude of the faster oscillation. The strength of this ‘phase-amplitude coupling’ is itself found to depend on the animals cognitive state and ongoing behaviour, and is therefore thought to play an important functional role. Despite the importance of this phenomenon, its biophysical origin and the reasons for its ubiquity across brain regions and species remain unclear. Here, using a data-driven physiologically detailed computational model of hippocampal CA1, we show how a basic microcircuit can autonomously generate both theta and gamma which are phase-amplitude coupled. The results suggests that the underlying dynamical mechanism is very general, and will be relevant in multiple different neural settings.
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影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
DOI：
10.1523/jneurosci.5110-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ahmed OJ;Mehta MR
通讯作者：
Mehta MR
影响因子：
3.5
作者：
Ecker A;Romani A;Sáray S;Káli S;Migliore M;Falck J;Lange S;Mercer A;Thomson AM;Muller E;Reimann MW;Ramaswamy S
通讯作者：
Ramaswamy S
影响因子：
16.2
作者：
Amilhon, Benedicte;Huh, Carey Y. L.;Williams, Sylvain
通讯作者：
Williams, Sylvain
影响因子：
16.6
作者：
Etter, Guillaume;van der Veldt, Suzanne;Williams, Sylvain
通讯作者：
Williams, Sylvain