The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay?
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DOI：
10.3390/nu12092648
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发表时间：
2020-08-31
期刊：
影响因子：
5.9
通讯作者：
Di Domenico M
中科院分区：
文献类型：
--
作者：
Crocetto F;Boccellino M;Barone B;Di Zazzo E;Sciarra A;Galasso G;Settembre G;Quagliuolo L;Imbimbo C;Boffo S;Angelillo IF;Di Domenico M
人类微生物群在泌尿系统健康和疾病中发挥着关键作用。新兴的研究表明，肠道和尿液微生物组可以影响良性和恶性的几种泌尿系统疾病，特别是前列腺炎症和前列腺癌。实际上，微生物群通过响应于不同的致病性noxae调节慢性炎症、凋亡过程、细胞因子和激素产生来对前列腺癌起始和/或进展机制施加其影响。此外，治疗和药物的反应在其功效和耐受性方面受到微生物群组成的影响。由于前列腺癌和微生物群之间的这种复杂的潜在相互联系，探索和理解所涉及的关系对于评估临床实践中的潜在治疗应用至关重要。此外，几种天然化合物似乎对泌尿系统健康具有直接或由微生物群介导的相关影响，使人类微生物群处于前列腺炎症和前列腺癌发展之间的十字路口。在这里，我们的目标是分析关于前列腺，微生物组和炎症之间可能的串扰的最新证据。
The human microbiota shows pivotal roles in urologic health and disease. Emerging studies indicate that gut and urinary microbiomes can impact several urological diseases, both benignant and malignant, acting particularly on prostate inflammation and prostate cancer. Indeed, the microbiota exerts its influence on prostate cancer initiation and/or progression mechanisms through the regulation of chronic inflammation, apoptotic processes, cytokines, and hormonal production in response to different pathogenic noxae. Additionally, therapies’ and drugs’ responses are influenced in their efficacy and tolerability by microbiota composition. Due to this complex potential interconnection between prostate cancer and microbiota, exploration and understanding of the involved relationships is pivotal to evaluate a potential therapeutic application in clinical practice. Several natural compounds, moreover, seem to have relevant effects, directly or mediated by microbiota, on urologic health, posing the human microbiota at the crossroad between prostatic inflammation and prostate cancer development. Here, we aim to analyze the most recent evidence regarding the possible crosstalk between prostate, microbiome, and inflammation.
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影响因子：
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作者：
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影响因子：
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DOI：
10.1186/s13046-019-1461-z
发表时间：
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影响因子：
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作者：
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