Model studies of the role of oxygen in the FLASH effect.
Model studies of the role of oxygen in the FLASH effect.
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DOI：
10.1002/mp.15129
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发表时间：
2022-03
期刊：
影响因子：
3.8
通讯作者：
Limoli CL
中科院分区：
文献类型：
--
作者：
Favaudon V;Labarbe R;Limoli CL
目前的放射治疗设施被标准化为以每天2戈伊分次输送约0.1-0.4戈伊/s的剂量率，设计为输送总累积剂量以达到接受照射的正常组织的耐受极限。另一方面，FLASH放射疗法（FLASH-RT）依赖于能够在单个微秒脉冲中或在非常短的时间序列内给出的几个脉冲中以大剂量递送可接受剂量率的设施。例如，迄今为止的大多数研究已经实现了4-6 MeV的电子，其中脉冲内剂量率在106-107戈伊/s的范围内。提出的闪光效应对氧张力的依赖性刺激了基于三种不同假设的几种理论模型：（i）辐射诱导的瞬时氧消耗;（ii）细胞特异性解毒和/或从活性氧引起的损伤中恢复的能力差异;（iii）通过双分子重组的自由基自湮灭。本文着重于观察支持或反驳这些模型的框架内的化学-生物学基础的影响，氧对细胞的辐射响应，在体外和体内模型系统。
Current radiotherapy facilities are standardized to deliver dose rates around 0.1-0.4 Gy/s in 2 Gy daily fractions, designed to deliver total accumulated doses to reach the tolerance limit of normal tissues undergoing irradiation. FLASH radiotherapy (FLASH-RT) on the other hand, relies on facilities capable of delivering ultrahigh dose rates in large doses in a single microsecond pulse, or in a few pulses given over a very short time sequence. For example, most studies to date have implemented 4-6 MeV electrons with intra-pulse dose rates in the range 106-107 Gy/s. The proposed dependence of the FLASH effect on oxygen tension has stimulated several theoretical models based on three different hypotheses: (i) Radiation-induced transient oxygen depletion; (ii) Cell-specific differences in the ability to detoxify and/or recover from injury caused by reactive oxygen species; (iii) Self-annihilation of radicals by bimolecular recombination. This article focuses on the observations supporting or refuting these models in the frame of the chemical-biological bases of the impact of oxygen on the radiation response of cell free, in vitro and in vivo model systems.
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发表时间：
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影响因子：
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作者：
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发表时间：
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影响因子：
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