Altered frontal-mediated inhibition and white matter connectivity in pediatric chronic tic disorders.
Altered frontal-mediated inhibition and white matter connectivity in pediatric chronic tic disorders.
复制标题
儿童慢性抽动障碍中额叶介导的抑制和白色连接的改变。
DOI：
10.1007/s00221-020-06017-0
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发表时间：
2021-03
影响因子：
2
通讯作者：
Wu, Steve W.
中科院分区：
文献类型：
--
作者：
Bruce, Adrienne B.;Yuan, Weihong;Gilbert, Donald L.;Horn, Paul S.;Jackson, Hannah S.;Huddleston, David A.;Wu, Steve W.
关键词：
抽搐是与大多数运动障碍不同的，因为它们是部分可抑制的。作为抑制运动网络的一部分，前辅助运动区参与运动控制，并可能参与抽动生理。我们使用双部位经颅磁刺激来评估右侧前补充运动区和左侧初级运动皮质之间的抑制性连接，这在以前已经在健康成年人中得到证实。我们还使用扩散张量成像来研究慢性抽搐儿童脑白质的连通性。对12例慢性抽动障碍儿童和14例典型发育期儿童进行磁共振弥散张量成像指数分析，然后进行单脉冲和双脉冲经颅磁刺激，条件脉冲位于右侧前辅助运动区，然后进行左侧运动皮质测试脉冲。抽动症患者的神经生理学和影像数据与抽动严重程度和可抑制性的测量之间的关系也被评估。在健康对照组儿童中存在运动前辅助区域介导的左侧运动皮质抑制，而在慢性抽动障碍参与者中则不存在。抑制程度越低，抽动抑制能力越差(ρ=−为0.73，p=0.047)。影像分析显示抽动症患者右上纵束、胼胝体、放射冠和内囊后肢的各向异性分数增加(p<；0.05)，这与自述的抽动抑制能力降低(ρ=−0.70，p=0.05)相关。生理数据显示慢性抽动症参与者额叶介导的运动皮质抑制受损，影像分析显示运动通路异常。总的来说，神经生理学和神经解剖学数据与抽动抑制相关，支持与抽动病理生理学的相关性。
Tics are unique from most movement disorders, in that they are partially suppressible. As part of the inhibitory motor network, the pre-supplementary motor area is engaged in motor control and may be involved in tic physiology. We used dual-site transcranial magnetic stimulation to assess inhibitory connectivity between right pre-supplementary motor area and left primary motor cortex, which has previously been demonstrated in healthy adults. We also used diffusion tensor imaging to investigate white matter connectivity in children with chronic tics. Twelve children with chronic tic disorder and fourteen typically developing controls underwent MRI with diffusion tensor imaging indices analysis followed by single and paired-pulse transcranial magnetic stimulation with conditioning pulse over the right pre-supplementary motor area followed by left motor cortex test pulse. Neurophysiologic and imaging data relationships to measures of tic severity and suppressibility were also evaluated in tic patients. Pre-supplementary motor area-mediated inhibition of left motor cortex was present in healthy control children but not in chronic tic disorder participants. Less inhibition correlated with worse tic suppressibility (ρ = − 0.73, p = 0.047). Imaging analysis showed increased fractional anisotropy in the right superior longitudinal fasciculus, corpus callosum, corona radiata and posterior limb of the internal capsule (p < 0.05) in tic participants, which correlated with lower self-reported tic suppressibility (ρ = − 0.70, p = 0.05). Physiologic data revealed impaired frontal-mediated motor cortex inhibition in chronic tic participants, and imaging analysis showed abnormalities in motor pathways. Collectively, the neurophysiologic and neuroanatomic data correlate with tic suppressibility, supporting the relevancy to tic pathophysiology.
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DOI：
10.1093/brain/awq300
发表时间：
2010-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Draganski B;Martino D;Cavanna AE;Hutton C;Orth M;Robertson MM;Critchley HD;Frackowiak RS
通讯作者：
Frackowiak RS
影响因子：
2.9
作者：
Conelea, Christine A.;Woods, Douglas W.;Walkup, John
通讯作者：
Walkup, John
DOI：
10.7916/d8445k68
发表时间：
2012-01-01
期刊：
Tremor and other hyperkinetic movements (New York, N.Y.)
影响因子：
--
作者：
Cubo, Esther
通讯作者：
Cubo, Esther
影响因子：
10.6
作者：
Aron, Adam R.
通讯作者：
Aron, Adam R.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y