Multispectral brain morphometry in Tourette syndrome persisting into adulthood.
Multispectral brain morphometry in Tourette syndrome persisting into adulthood.
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DOI：
10.1093/brain/awq300
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Frackowiak RS
中科院分区：
文献类型：
--
作者：
Draganski B;Martino D;Cavanna AE;Hutton C;Orth M;Robertson MM;Critchley HD;Frackowiak RS
Tourette综合征是一种儿童期发病的神经精神障碍，具有高患病率的注意缺陷多动和强迫症共病。在儿童和青少年的额叶皮层和纹状体中发现了结构变化。少数持续到成年期的抽动秽语综合征的形态测量学研究表明，影响额纹状体回路的持续结构改变。使用皮质厚度估计和基于体素的分析T1和弥散加权结构磁共振图像，我们检查了40例成人抽动秽语综合征与40名年龄和性别匹配的健康对照。Tourette综合征患者双侧眶额、前扣带回和腹外侧前额叶皮质的灰质体积相对减少。皮质变薄延伸到边缘内侧颞叶。灰质的变化还受到合并症和症状严重程度的影响。前额叶皮层厚度减少与抽搐严重程度呈负相关，而初级躯体感觉皮层的体积增加取决于先兆感觉的强度。眶额皮质体积的变化进一步与灰质内的水扩散异常相关。白色物质分析揭示了抽动秽语综合征患者胼胝体前部纤维连贯性的变化。运动抽搐和先兆冲动的严重程度对皮质-皮质和皮质-皮质下连接对应的神经束的完整性产生了影响。我们的研究结果提供了经验支持的病理学模型的抽动秽语综合征的基础上发育异常，扰动的补偿系统标记持续到成年期的症状。我们解释症状严重程度相关的灰质体积增加，在不同的功能脑区的证据正在进行的结构可塑性。从体积和水扩散成像的证据的收敛加强了我们的研究结果的有效性，并证明了一种新的多模态组合的体积和皮质厚度的估计，提供独特的和互补的信息，通过利用他们的差异敏感性结构变化的价值。
Tourette syndrome is a childhood-onset neuropsychiatric disorder with a high prevalence of attention deficit hyperactivity and obsessive-compulsive disorder co-morbidities. Structural changes have been found in frontal cortex and striatum in children and adolescents. A limited number of morphometric studies in Tourette syndrome persisting into adulthood suggest ongoing structural alterations affecting frontostriatal circuits. Using cortical thickness estimation and voxel-based analysis of T1- and diffusion-weighted structural magnetic resonance images, we examined 40 adults with Tourette syndrome in comparison with 40 age- and gender-matched healthy controls. Patients with Tourette syndrome showed relative grey matter volume reduction in orbitofrontal, anterior cingulate and ventrolateral prefrontal cortices bilaterally. Cortical thinning extended into the limbic mesial temporal lobe. The grey matter changes were modulated additionally by the presence of co-morbidities and symptom severity. Prefrontal cortical thickness reduction correlated negatively with tic severity, while volume increase in primary somatosensory cortex depended on the intensity of premonitory sensations. Orbitofrontal cortex volume changes were further associated with abnormal water diffusivity within grey matter. White matter analysis revealed changes in fibre coherence in patients with Tourette syndrome within anterior parts of the corpus callosum. The severity of motor tics and premonitory urges had an impact on the integrity of tracts corresponding to cortico-cortical and cortico-subcortical connections. Our results provide empirical support for a patho-aetiological model of Tourette syndrome based on developmental abnormalities, with perturbation of compensatory systems marking persistence of symptoms into adulthood. We interpret the symptom severity related grey matter volume increase in distinct functional brain areas as evidence of ongoing structural plasticity. The convergence of evidence from volume and water diffusivity imaging strengthens the validity of our findings and attests to the value of a novel multimodal combination of volume and cortical thickness estimations that provides unique and complementary information by exploiting their differential sensitivity to structural change.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.7
作者：
Eickhoff, Simon B.;Grefkes, Christian;Fink, Gereon R.
通讯作者：
Fink, Gereon R.
影响因子：
11.2
作者：
Garraux, G;Goldfine, A;Hallett, M
通讯作者：
Hallett, M
影响因子：
4.7
作者：
Gerard, E;Peterson, BS
通讯作者：
Peterson, BS
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D