Beyond DNA origami: the unfolding prospects of nucleic acid nanotechnology.

Beyond DNA origami: the unfolding prospects of nucleic acid nanotechnology.
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超越 DNA 折纸:核酸纳米技术的前景。

DOI:
10.1002/wnan.170
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发表时间:
2012-03
影响因子:
8.6
通讯作者:
Walter, Nils G.
Walter, Nils G.
中科院分区:
医学2区
文献类型:
--
作者:
Michelotti, Nicole;Johnson-Buck, Alexander;Manzo, Anthony J.;Walter, Nils G.

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核酸纳米技术利用天然和合成核酸的可编程分子识别特性,以纳米级精度组装结构。2006年,DNA折纸通过提供一个多功能平台来改变该领域,该平台用于从一条长DNA链通过数百个短的、位点特异性(空间可寻址)DNA“斯台普斯”进行任意形状的自组装。这种革命性的方法导致了大量2D和3D支架的产生,这些支架构成了功能性纳米器件的基础。不限于核酸,这些纳米器件可以包含其他结构和功能材料,如蛋白质和纳米颗粒,使它们广泛用于当前和未来的新兴领域,如纳米医学,纳米电子学和替代能源。
Nucleic acid nanotechnology exploits the programmable molecular recognition properties of natural and synthetic nucleic acids to assemble structures with nanometer-scale precision. In 2006, DNA origami transformed the field by providing a versatile platform for self-assembly of arbitrary shapes from one long DNA strand held in place by hundreds of short, site-specific (spatially addressable) DNA ”staples”. This revolutionary approach has led to the creation of a multitude of 2D and 3D scaffolds that form the basis for functional nanodevices. Not limited to nucleic acids, these nanodevices can incorporate other structural and functional materials, such as proteins and nanoparticles, making them broadly useful for current and future applications in emerging fields such as nanomedicine, nanoelectronics, and alternative energy.
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