β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.
β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.
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DOI：
10.1002/mnfr.201901071
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发表时间：
2021-01
影响因子：
5.2
通讯作者：
Roche HM
中科院分区：
文献类型：
--
作者：
De Marco Castro E;Calder PC;Roche HM
先天免疫系统以快速和非特异性的方式对免疫威胁做出反应;炎症是这种反应的一部分。随后是较慢但有针对性和特异性的反应，称为适应性或获得性免疫反应。有新的证据表明，饮食成分，包括酵母衍生的β-葡聚糖，可以通过调节中性粒细胞和巨噬细胞的炎症和抗菌活性来帮助宿主防御病原体。先天免疫训练是指一种新认识到的现象，其中化合物可以“训练”先天免疫细胞，使得单核细胞和巨噬细胞前体生物学被改变以产生更有效的免疫应答。虽然已经进行了各种人体研究，但仍存在许多不确定性，需要进一步研究以充分阐明β葡聚糖补充剂与人体免疫功能之间的关系。本综述提供了有关酵母源β-葡聚糖作为免疫调节剂的最新报告，包括有关β-葡聚糖与免疫系统相互作用的当前范式的简要概述。最近的临床前工作，部分解密的作用方式和最新的证据，从人体试验也进行了审查。根据临床前研究，来源于面包酵母的β-1，3/1，6-葡聚糖可增强免疫监视，尽管人体证据弱于临床前研究。新出现的证据表明，膳食成分，如β-葡聚糖，可以通过调节中性粒细胞和巨噬细胞的炎症和抗菌活性来帮助宿主防御。这种属性可以追溯到先天免疫训练，其中经典先天免疫细胞与病原体相关分子模式之间的第一次相遇触发细胞内功能变化，从而加速未来对相同或不相关病原体的防御。
The innate immune system responds in a rapid and non‐specific manner against immunologic threats; inflammation is part of this response. This is followed by a slower but targeted and specific response termed the adaptive or acquired immune response. There is emerging evidence that dietary components, including yeast‐derived β‐glucans, can aid host defense against pathogens by modulating inflammatory and antimicrobial activity of neutrophils and macrophages. Innate immune training refers to a newly recognized phenomenon wherein compounds may “train” innate immune cells, such that monocyte and macrophage precursor biology is altered to mount a more effective immunological response. Although various human studies have been carried out, much uncertainty still exists and further studies are required to fully elucidate the relationship between β‐glucan supplementation and human immune function. This review offers an up‐to‐date report on yeast‐derived β‐glucans as immunomodulators, including a brief overview of the current paradigm regarding the interaction of β‐glucans with the immune system. The recent pre‐clinical work that has partly decrypted mode of action and the newest evidence from human trials are also reviewed. According to pre‐clinical studies, β‐1,3/1,6‐glucan derived from baker's yeast may offer increased immuno‐surveillance, although the human evidence is weaker than that gained from pre‐clinical studies. Emerging evidence indicates that dietary components, like β‐glucans, can aid host defense by modulating the inflammatory and antimicrobial activity of neutrophils and macrophages. This attribute is traced to innate immune training, wherein the first encounter between classical innate immune cells and a pathogen‐associated molecular pattern triggers intracellular functional changes that expedite future defense toward the same or an unrelated pathogen.
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Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
影响因子：
11.2
作者：
Bohn, JA;BeMiller, JN
通讯作者：
BeMiller, JN
影响因子：
12.4
作者：
BOUSQUET, J;DHIVERT, H;MICHEL, FB
通讯作者：
MICHEL, FB
影响因子：
--
作者：
Briefel, RR;Reidy, K;Devaney, B
通讯作者：
Devaney, B
影响因子：
7
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.