Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children.
Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children.
复制标题
肥胖相关基因6个单核苷酸多态性与中国儿童BMI和肥胖风险的关系
作者：
Wu L;Xi B;Zhang M;Shen Y;Zhao X;Cheng H;Hou D;Sun D;Ott J;Wang X;Mi J
目的儿童肥胖是成人某些疾病的易感因素。最近，高加索人的全基因组关联(GWA)研究发现了与BMI和肥胖相关的多个单核苷酸多态(SNPs)。在其他种族中，这些SNP与BMI和肥胖症的关联并没有得到充分的描述，特别是在儿童中。在这些已发现的SNPs中，我们选择了6个(rs7138803、rs1805081、rs6499640、rs17782313、rs6265和rs10938397，分别位于或接近肥胖相关基因FAIM2、NPC1、FTO、MC4R、BDNF和GNPDA2)，并检测了这些SNPs与中国儿童BMI和肥胖的关系。研究设计与方法我们调查了这些SNPs与学龄儿童BMI和肥胖的关系。共有3503名儿童参与了这项研究，其中包括1229名肥胖儿童、655名超重儿童和1619名正常体重儿童(根据中国特定年龄和性别的BMI临界值诊断)。结果在中国儿童中，经年龄、性别调整和多重检验校正后，rs17782313、rs6265和rs10938397与体重指数(P值分别为1.0×10−5、0.038和0.00093)和肥胖(P值分别为5.0×10−6、0.043和0.00085)相关。SNP rs17782313和rs10938397也与腰围、腰高比和脂肪质量百分比显著相关。结论本研究结果支持成人肥胖相关基因是儿童BMI变异的重要基因，GWA研究在高加索人群中发现的一些SNP也可能导致中国儿童肥胖。
OBJECTIVE Childhood obesity strongly predisposes to some adult diseases. Recently, genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with BMI and obesity. The associations of those SNPs with BMI and obesity among other ethnicities are not fully described, especially in children. Among those previously identified SNPs, we selected six (rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with BMI and obesity in Chinese children. RESEARCH DESIGN AND METHODS We investigated the associations of these SNPs with BMI and obesity in school-aged children. A total of 3,503 children participated in the study, including 1,229 obese, 655 overweight, and 1,619 normal-weight children (diagnosed by the Chinese age- and sex-specific BMI cutoffs). RESULTS After age and sex adjustment and correction for multiple testing, the SNPs rs17782313, rs6265, and rs10938397 were associated with BMI (P = 1.0 × 10−5, 0.038, and 0.00093, respectively) and also obesity (P = 5.0 × 10−6, 0.043, and 0.00085, respectively) in the Chinese children. The SNPs rs17782313 and rs10938397 were also significantly associated with waist circumference, waist-to-height ratio, and fat mass percentage. CONCLUSIONS Results of this study support obesity-related genes in adults as important genes for BMI variation in children and suggest that some SNPs identified by GWA studies in Caucasians also confer risk for obesity in Chinese children.
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影响因子：
--
作者：
Wang, Youfa;Lobstein, Tim
通讯作者：
Lobstein, Tim
影响因子：
7
作者：
Heid, CA;Stevens, J;Williams, PM
通讯作者：
Williams, PM
影响因子：
5.8
作者：
Cheung, Chloe Y. Y.;Tso, Annette W. K.;Lam, Karen S. L.
通讯作者：
Lam, Karen S. L.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
30.8
作者：
Loos, Ruth J. F.;Lindgren, Cecilia M.;Li, Shengxu;Wheeler, Eleanor;Zhao, Jing Hua;Prokopenko, Inga;Inouye, Michael;Freathy, Rachel M.;Attwood, Antony P.;Beckmann, Jacques S.;Berndt, Sonja I.;Bergmann, Sven;Bennett, Amanda J.;Bingham, Sheila A.;Bochud, Murielle;Brown, Morris;Cauchi, Stephane;Connell, John M.;Cooper, Cyrus;Smith, George Davey;Day, Ian;Dina, Christian;De, Subhajyoti;Dermitzakis, Emmanouil T.;Doney, Alex S. F.;Elliott, Katherine S.;Elliott, Paul;Evans, David M.;Farooqi, I. Sadaf;Froguel, Philippe;Ghori, Jilur;Groves, Christopher J.;Gwilliam, Rhian;Hadley, David;Hall, Alistair S.;Hattersley, Andrew T.;Hebebrand, Johannes;Heid, Iris M.;Herrera, Blanca;Hinney, Anke;Hunt, Sarah E.;Jarvelin, Marjo-Riitta;Johnson, Toby;Jolley, Jennifer D. M.;Karpe, Fredrik;Keniry, Andrew;Khaw, Kay-Tee;Luben, Robert N.;Mangino, Massimo;Marchini, Jonathan;McArdle, Wendy L.;McGinnis, Ralph;Meyre, David;Munroe, Patricia B.;Morris, Andrew D.;Ness, Andrew R.;Neville, Matthew J.;Nica, Alexandra C.;Ong, Ken K.;O'Rahilly, Stephen;Owen, Katharine R.;Palmer, Colin N. A.;Papadakis, Konstantinos;Potter, Simon;Pouta, Anneli;Qi, Lu;Randall, Joshua C.;Rayner, Nigel W.;Ring, Susan M.;Sandhu, Manjinder S.;Scherag, Andre;Sims, Matthew A.;Song, Kijoung;Soranzo, Nicole;Speliotes, Elizabeth K.;Syddall, Holly E.;Teichmann, Sarah A.;Timpson, Nicholas J.;Tobias, Jonathan H.;Uda, Manuela;Vogel, Carla I. Ganz;Wallace, Chris;Waterworth, Dawn M.;Weedon, Michael N.;Willer, Cristen J.;Wraight, Vicki L.;Yuan, Xin;Zeggini, Eleftheria;Hirschhorn, Joel N.;Strachan, David P.;Ouwehand, Willem H.;Caulfield, Mark J.;Samani, Nilesh J.;Frayling, Timothy M.;Vollenweider, Peter;Waeber, Gerard;Mooser, Vincent;Deloukas, Panos;McCarthy, Mark I.;Wareham, Nicholas J.;Barroso, Ines
通讯作者：
Barroso, Ines