Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries
Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries
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臂丛神经撕脱伤对侧第七颈脊神经根移植后大鼠初级运动皮层 miR-132、miR-134 和 miR-485 在跨半球功能重组过程中的表达
DOI：
10.1097/wnr.0000000000000485
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发表时间：
2016-01
期刊：
影响因子：
1.7
通讯作者：
Yudong Gu
中科院分区：
文献类型：
--
作者：
Guixin Sun;Zuopei Wu;Jifeng Li;Yudong Gu
将健侧第七颈脊神经根（cC 7）转移至受损侧的受体神经被认为是恢复臂丛根性撕脱伤（BPAI）后受伤手生理功能的有希望的方法。越来越多的证据表明，跨半球皮质重组在cC 7神经移位手术后受损手臂的功能恢复中起着重要作用。然而，cC 7转移后transmispheric皮质重组的分子机制仍然难以捉摸。在本研究中，我们研究了miR-132，miR-134，和miR-485在大鼠初级运动皮层cC 7转移后BPAI的表达通过定量PCR。结果表明，在BPAI后转移cC 7后，大鼠初级运动皮层中miR-132、miR-134和miR-485的表达发生动态变化。这表明microRNA参与了BPAI后cC 7根转移后的动态跨半球功能重组。总而言之，这项研究是第一个为BPAI后cC 7转移后动态跨半球功能重组过程中微小RNA的参与提供证据的研究。本研究结果有助于了解BPAI后健侧第7颈脊神经根移位后跨半球功能重组的机制。
The transfer of a contralateral healthy seventh cervical spinal nerve root (cC7) to the recipient nerve in the injured side is considered a promising procedure for restoration of the physiological functions of an injured hand after brachial plexus root avulsion injury (BPAI). Growing evidence shows that transhemispheric cortical reorganization plays an important role in the functional recovery of the injured arm after cC7 nerve transfer surgery. However, the molecular mechanism underlying the transhemispheric cortical reorganization after cC7 transfer remains elusive. In the present study, we investigated the expression of miR-132, miR-134, and miR-485 in the rat primary motor cortex after cC7 transfer following BPAI by quantitative PCR. The results demonstrated the dynamic alteration in the expression of miR-132, miR-134, and miR-485 in the primary motor cortex of rats after cC7 transfer following BPAI. It indicates that microRNAs are involved in the dynamic transhemispheric functional reorganization after cC7 root transfer following BPAI. Together, this study is the first to provide evidence for the involvement of microRNAs during dynamic transhemispheric functional reorganization after cC7 transfer following BPAI. The results are useful for understanding the mechanism underlying transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following BPAI.
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影响因子：
25
作者：
Tognini P;Putignano E;Coatti A;Pizzorusso T
通讯作者：
Pizzorusso T
DOI：
10.1073/pnas.1015691107
发表时间：
2010-11-23
影响因子：
11.1
作者：
Magill, Stephen T.;Cambronne, Xiaolu A.;Goodman, Richard H.
通讯作者：
Goodman, Richard H.
DOI：
10.1073/pnas.1017576108
发表时间：
2011-07-12
影响因子：
11.1
作者：
Cohen, Jonathan E.;Lee, Philip R.;Fields, R. Douglas
通讯作者：
Fields, R. Douglas
DOI：
10.1073/pnas.0508448102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Vo, N;Klein, ME;Impey, S
通讯作者：
Impey, S
影响因子：
5.3
作者：
Elramah S;Landry M;Favereaux A
通讯作者：
Favereaux A