MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms.
MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms.
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DOI：
10.3389/fncel.2014.00031
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发表时间：
2014
影响因子：
5.3
通讯作者：
Favereaux A
中科院分区：
文献类型：
--
作者：
Elramah S;Landry M;Favereaux A
microRNA（miRNAs）作为神经系统中基因表达的主要调节因子正在出现，在神经系统中它们不仅有助于大脑发育，而且还有助于神经网络的稳态和可塑性。它们的功能是一系列事件的结果，包括miRNA生物合成、靶点识别和翻译抑制。有研究表明，miRNA是基因组的主要开关，因为它们能够同时调节多个基因。这种调节对于正常的神经元活动是必不可少的，并且当受到影响时，可以导致严重的病理状况。作为一个例子，我们说明了miRNAs的失调如何影响神经元的可塑性，导致慢性疼痛。疼痛的起源及其作为一种关键生理功能和一种使人衰弱的疾病的双重作用一直备受争议。据估计，慢性疼痛的发病率在全球范围内为20-25%，因此使其成为公共卫生问题。慢性疼痛可以被认为是一种适应不良的可塑性。持久的修饰是基因表达整体变化的结果，因此可能受到miRNA的控制。在这里，我们回顾了有关miRNAs及其靶点在慢性疼痛条件下适应不良可塑性的文献。此外，我们对不同疼痛模型的miRNA表达数据进行了回顾性分析，考虑到我们对miRNA在神经元可塑性中作用的理解的最新进展。
MicroRNAs (miRNAs) are emerging as master regulators of gene expression in the nervous system where they contribute not only to brain development but also to neuronal network homeostasis and plasticity. Their function is the result of a cascade of events including miRNA biogenesis, target recognition, and translation inhibition. It has been suggested that miRNAs are major switches of the genome owing to their ability to regulate multiple genes at the same time. This regulation is essential for normal neuronal activity and, when affected, can lead to drastic pathological conditions. As an example, we illustrate how deregulation of miRNAs can affect neuronal plasticity leading to chronic pain. The origin of pain and its dual role as a key physiological function and a debilitating disease has been highly debated until now. The incidence of chronic pain is estimated to be 20–25% worldwide, thus making it a public health problem. Chronic pain can be considered as a form of maladaptive plasticity. Long-lasting modifications develop as a result of global changes in gene expression, and are thus likely to be controlled by miRNAs. Here, we review the literature on miRNAs and their targets responsible for maladaptive plasticity in chronic pain conditions. In addition, we conduct a retrospective analysis of miRNA expression data published for different pain models, taking into account recent progress in our understanding of the role of miRNAs in neuronal plasticity.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
DOI：
10.1523/jneurosci.0558-12.2012
发表时间：
2012-06-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Åkerblom M;Sachdeva R;Barde I;Verp S;Gentner B;Trono D;Jakobsson J
通讯作者：
Jakobsson J
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
64.5
作者：
Ashraf, SI;McLoon, AL;Kunes, S
通讯作者：
Kunes, S
影响因子：
16.2
作者：
Campbell, DS;Holt, CE
通讯作者：
Holt, CE