Absent movement-related cortical potentials in children with primary motor stereotypies.
Absent movement-related cortical potentials in children with primary motor stereotypies.
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DOI：
10.1002/mds.25753
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发表时间：
2014-08
影响因子：
8.6
通讯作者：
Hallett, Mark
中科院分区：
文献类型：
--
作者：
Houdayer, Elise;Walthall, Jessica;Belluscio, Beth A.;Vorbach, Sherry;Singer, Harvey S.;Hallett, Mark
儿童复杂运动刻板症的潜在病理生理机制尚不清楚，其假设从觉醒到运动控制障碍不等。运动相关皮层电位（MRCPs），代表参与运动产生的大脑区域的激活，先于并伴随自主运动。本研究的目的是比较与刻板印象相关的大脑活动与原发性复杂运动刻板印象儿童的自愿运动。对10例原发性运动刻板症患儿和7例正常儿童进行了同步录像脑电图（EEG）记录。分析与刻板行为和自主调节手臂运动相关的EEG活动是否存在早期或晚期MRCP，即在自主运动开始前约1秒开始的陡峭负性。在10名运动刻板症儿童中有8名和7名对照儿童中有6名进行了早期MRCP。观察到的MRCP在组间无差异。在出现复杂的运动刻板症之前，没有发现MRCP。与自愿运动不同，刻板印象之前没有MRCP。这表明运动前区可能不参与这些复杂动作的准备，并表明刻板印象是由不同于自愿运动的机制发起的。需要进一步的研究来确定皮质-纹状体-丘脑-皮质通路内运动控制异常的部位，并确定是否在继发性刻板症儿童中发现类似的结果。
The underlying pathophysiologic mechanism for complex motor stereotypies in children is unknown with hypotheses ranging from an arousal to a motor control disorder. Movement-related cortical potentials (MRCPs), representing the activation of cerebral areas involved in the generation of movements, precede and accompany self-initiated voluntary movements. The goal of this study was to compare cerebral activity associated with stereotypies to that seen with voluntary movements in children with primary complex motor stereotypies. Electroencephalographic (EEG) activity synchronized with video recording was recorded in 10 children diagnosed with primary motor stereotypies and 7 controls. EEG activity related to stereotypies and self-paced arm movements were analyzed for presence or absence of early or late MRCP, a steep negativity beginning about one second before the onset of a voluntary movement. Early MRCPs preceded self-paced arm movements in 8 out of 10 children with motor stereotypies and in 6 out of 7 controls. Observed MRCPs did not differ between groups. No MRCP was identified before the appearance of a complex motor stereotypy. Unlike voluntary movements, stereotypies are not preceded by MRCPs. This indicates that premotor areas are likely not involved in the preparation of these complex movements and suggests that stereotypies are initiated by mechanisms different from voluntary movements. Further studies are required to determine the site of the motor control abnormality within cortico-striatal-thalamo-cortical pathways and to identify whether similar findings would be found in children with secondary stereotypies.
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影响因子：
25
作者：
Canales, JJ;Graybiel, AM
通讯作者：
Graybiel, AM
影响因子：
3.6
作者：
ARNT, J
通讯作者：
ARNT, J
影响因子：
3.8
作者：
Kates, WR;Lanham, DC;Singer, HS
通讯作者：
Singer, HS
影响因子：
2
作者：
Hallett, Mark
通讯作者：
Hallett, Mark
影响因子：
14.5
作者：
Aliane, Verena;Perez, Sylvie;Kemel, Marie-Louise
通讯作者：
Kemel, Marie-Louise