RNA helicases and abiotic stress.
RNA helicases and abiotic stress.
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DOI：
10.1093/nar/gkl408
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发表时间：
2006
影响因子：
14.9
通讯作者：
Owttrim GW
中科院分区：
文献类型：
--
作者：
Owttrim GW
RNA解旋酶作为分子马达，重新排列RNA二级结构，可能在涉及RNA代谢的任何细胞过程中发挥作用。虽然RNA解旋酶与一系列细胞功能的关联是有据可查的，但它们在应对非生物胁迫中的重要性才刚刚开始出现。本文综述了非生物胁迫对RNA解旋酶的表达、生物化学和生理功能的影响。实例主要源自非哺乳动物生物体，而来自哺乳动物来源的实例限于解旋酶生化活性的翻译后调节。共同出现的主题包括在非恒温生物体中的冷诱导解旋酶的要求，解旋酶活性的协会和调节的压力诱导的磷酸化级联，改变核质穿梭在真核生物中，协会与转录装置和生化活动的多样性催化的压力诱导的解旋酶的一个亚组。这些数据被放置在RNA解旋酶参与细胞对非生物胁迫的反应机制的背景下。有人提出，压力调节解旋酶可以催化一个非线性的，可逆的序列的RNA二级结构重排，在RNA成熟或RNA校对功能，提供了一种机制，通过解旋酶活性改变目标RNA的激活状态，通过调节反应平衡。
RNA helicases function as molecular motors that rearrange RNA secondary structure, potentially performing roles in any cellular process involving RNA metabolism. Although RNA helicase association with a range of cellular functions is well documented, their importance in response to abiotic stress is only beginning to emerge. This review summarizes the available data on the expression, biochemistry and physiological function(s) of RNA helicases regulated by abiotic stress. Examples originate primarily from non-mammalian organisms while instances from mammalian sources are restricted to post-translational regulation of helicase biochemical activity. Common emerging themes include the requirement of a cold-induced helicase in non-homeothermic organisms, association and regulation of helicase activity by stress-induced phosphorylation cascades, altered nuclear–cytoplasmic shuttling in eukaryotes, association with the transcriptional apparatus and the diversity of biochemical activities catalyzed by a subgroup of stress-induced helicases. The data are placed in the context of a mechanism for RNA helicase involvement in cellular response to abiotic stress. It is proposed that stress-regulated helicases can catalyze a nonlinear, reversible sequence of RNA secondary structure rearrangements which function in RNA maturation or RNA proofreading, providing a mechanism by which helicase activity alters the activation state of target RNAs through regulation of the reaction equilibrium.
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影响因子：
2.9
作者：
Bizebard, T;Ferlenghi, I;Dreyfus, M
通讯作者：
Dreyfus, M
影响因子：
56.9
作者：
Chuang, RY;Weaver, PL;Chang, TH
通讯作者：
Chang, TH
DOI：
10.1073/pnas.0407896101
发表时间：
2005-01-04
影响因子：
11.1
作者：
Huang, HR;Rowe, CE;Perlman, PS
通讯作者：
Perlman, PS
影响因子：
5.1
作者：
Boonyaratanakornkit, BB;Simpson, AJ;Clark, DS
通讯作者：
Clark, DS
影响因子：
3.2
作者：
Briolat, V;Reysset, G
通讯作者：
Reysset, G