Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions.

Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions.
复制标题

酵母 Agp2p 和 Agp3p 在营养不良的条件下充当氨基酸渗透酶。

DOI:
10.1016/j.bbrc.2003.11.172
复制
发表时间:
2004
影响因子:
3.1
通讯作者:
Garrett,JinnieM
Garrett,JinnieM
中科院分区:
生物学4区
文献类型:
--
作者:
Schreve,JamesL;Garrett,JinnieM

文献摘要

参考文献

被引文献

相似文献

AGP2基因和ORF YFL055w(这里称为AGP3)属于酵母氨基酸渗透酶基因家族的成员。对这些基因被破坏的多重突变菌株的生长分析表明,这两种基因都编码能够提供支链和其他氨基酸作为氮源的通透性。Agp2p和Agp3p都是对亮氨酸(Kmapp0.2-0.5 mM)的低亲和力渗透剂,在所测试的所有介质上的表达水平低于其他渗透剂。因此,这两个渗透膜似乎可以作为低亲和力、相对非特异性的渗透膜在细胞中具有多余的功能。AGP2和AGP3的转录水平很低,但在缺乏其他功能的普通氨基酸(Gap1p或Agp1p)的细胞中,AGP2和AGP3的转录增加。这些结果表明,当氮源有限和/或其他通透性不活跃时,Agp2p和Agp3p在氨基酸运输中发挥作用。
The gene AGP2 and the ORF YFL055w (here named AGP3) are classified as members of the yeast amino acid permease gene family. Analysis of the growth of multiply-mutant strains in which these genes are disrupted shows that both encode permeases capable of supplying branched chain, and other, amino acids as nitrogen source. Both Agp2p and Agp3p are low affinity permeases for leucine (Kmapp0.2–0.5mM) and are expressed at lower levels than other permeases on all media tested. Thus, it appears that these two permeases can function as low affinity, relatively non-specific, permeases with redundant functions in the cell. Transcription of AGP2 and AGP3 is very low but is increased in cells lacking other functional general amino acid permeases (Gap1p or Agp1p). These results suggest Agp2p and Agp3p function in amino acid transport when nitrogen sources are limiting and/or other permeases are inactive.
DOI: --
发表时间: 1970
期刊: European Journal of Biochemistry
影响因子: --
作者:
J. Béchet;M. Grenson;J. Wiame
通讯作者: J. Wiame
DOI: 10.1128/jb.52.3.293-301.1946
发表时间: 1946-01-01
影响因子: 3.2
作者:
WICKERHAM, LJ
通讯作者: WICKERHAM, LJ
“1972政权”日本安保体系下的台湾(中文)
DOI: --
发表时间: 2022
期刊:
影响因子: --
作者:
Barrett;B;Ohta;H.;and Trencher;G. "Prospects for Acceleration of Socio-Technical Transitions for Deep Decarbonization," pp. 400-414;青山瑠妙;福田円;舒旻「中国:EUとの脆弱な相互依存」pp. 247-271;福田円;青山瑠妙;青山瑠妙;青山瑠妙;福田円;青山瑠妙;福田円
通讯作者: 福田円
DOI: 10.1128/jb.178.7.2025-2029.1996
发表时间: 1996-04-01
影响因子: 3.2
作者:
Didion, T;Grauslund, M;Andersen, HA
通讯作者: Andersen, HA
DOI: 10.1128/jb.103.3.770-777.1970
发表时间: 1970-01-01
影响因子: 3.2
作者:
GRENSON, M;HOU, C;CRABEEL, M
通讯作者: CRABEEL, M