A systematic review of lung clearance index in non-cystic fibrosis, non-primary ciliary dyskinesia bronchiectasis.
A systematic review of lung clearance index in non-cystic fibrosis, non-primary ciliary dyskinesia bronchiectasis.
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非囊性纤维化、非原发性纤毛运动障碍、支气管扩张症肺清除指数的系统评价。
DOI：
10.1016/j.rmed.2022.106937
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发表时间：
2022
影响因子：
4.3
通讯作者：
Hine C
中科院分区：
文献类型：
--
作者：
Hine C
非囊性纤维化，非原发睫状肌运动障碍支气管扩张症(nCFnPCD-BE)发病率高，缺乏循证治疗，需要客观评估严重程度和评价治疗。肺清除指数(LCI)是衡量肺泡灌洗不均匀程度的指标，是一项敏感的疾病检测指标；结果在276条记录中，纳入了12篇文章，描述了横断面研究中的519名成人和儿科患者，涉及几个领域。1：LCI在检测疾病和严重程度方面有什么作用？LCI在成人中检测到疾病，在CT上区分支扩与对照组(AUC0.90~0.96)和轻、中、重度支扩(AUC0.73)。2：LCI与肺活量和影像有关吗？成人LCI与肺活量(r=0.37~−0.61)和儿科(r=0.6Reff)组的肺活量、CT征象和CT评分系统(改良−)相关。3：LCI与严重程度的主观评分有关吗？在成人中，LCI与圣乔治呼吸问卷(r=0.18)和支扩严重程度指数(r=0.45)相关。4：LCI是否识别对干预的反应？LCI在检查干预前LCI的研究中没有改变。总体研究质量是可变的。结论与CF中的数据相比，本综述没有发现确定LCI在支气管扩张儿童中的作用的高质量研究。在成人中，LCI是衡量疾病严重程度的敏感指标，并与临床评估工具相关。
BackgroundNon cystic fibrosis, non primary ciliary dyskinesia bronchiectasis (nCFnPCD-BE) results in significant morbidity with few evidence-based treatments.Objectiveassessments are required to assess severity and evaluate treatment. Lung clearance index (LCI) measures ventilation inhomogeneity and is a sensitive test of disease in CF; its use in nCFnPCD-BE is unclear.MethodsA systematic review of LCI in nCFnPCD-BE was performed using standard methodology (protocol registered on PROSPERO, University of York).ResultsOf 276 records identified, 12 articles, describing 519 adult and paediatric patients in cross-sectional studies were included, addressing several domains.1: What is the utility of LCI in detecting disease and severity?LCI detected disease in adults, differentiating bronchiectasis from controls (AUC 0.90 to 0.96) and mild from moderate/severe bronchiectasis on CT (AUC 0.73).2: Does LCI correlate with spirometry and imaging?LCI correlated with spirometry in adult (r = −0.37 to −0.61) and paediatric (r = −0.6) groups, signs of bronchiectasis on CT, and CT scoring systems (modified Reiff).3: Does LCI relate to subjective scores of severity?In adults, LCI correlated with St. George's Respiratory Questionnaire (r = 0.18) and Bronchiectasis Severity Index (r = 0.45).4: Does LCI identify response to intervention?LCI did not change in studies examining LCI pre-post intervention (adults treated for exacerbation and undergoing physiotherapy).Overall study quality was variable.ConclusionContrary to data in CF, the review did not identify good quality studies defining the role of LCI in children with bronchiectasis. In adults, LCI was a sensitive measure of disease severity and correlated with clinical assessment tools.
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DOI：
--
发表时间：
2013
期刊：
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2012
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