Adult somatic stem cells in the human parasite Schistosoma mansoni.
Adult somatic stem cells in the human parasite Schistosoma mansoni.
复制标题
作者：
Schistosomiasis is among the most prevalent human parasitic diseases, affecting more than 200 million people worldwide. The etiological agents of this disease are trematode flatworms (Schistosoma) that live and lay eggs within the vasculature of the host. These eggs lodge in host tissues, causing inflammatory responses that are the primary cause of morbidity. Because these parasites can live and reproduce within human hosts for decades, elucidating the mechanisms that promote their longevity is of fundamental importance. Although adult pluripotent stem cells, called neoblasts, drive long-term homeostatic tissue maintenance in long-lived free-living flatworms (e.g., planarians), and neoblast-like cells have been described in some parasitic tapeworms, little is known about whether similar cell types exist in any trematode species. Here, we describe a population of neoblast-like cells in the trematode Schistosoma mansoni. These cells resemble planarian neoblasts morphologically and share their ability to proliferate and differentiate into derivatives of multiple germ layers. Capitalizing on available genomic resources and RNAseq-based gene expression profiling, we find that these schistosome neoblast-like cells express a fibroblast growth factor receptor ortholog. Using RNA interference we demonstrate that this gene is required for the maintenance of these neoblast-like cells. Our observations suggest that adaptation of developmental strategies shared by free-living ancestors to modern-day schistosomes likely contributed to the success of these animals as long-lived obligate parasites. We expect that future studies deciphering the function of these neoblast-like cells will have important implications for understanding the biology of these devastating parasites.
登录
查看更多内容
影响因子：
4.6
作者：
Pearson, Bret J.;Alvarado, Alejandro Sanchez
通讯作者：
Alvarado, Alejandro Sanchez
影响因子：
56.9
作者：
Davies, SJ;Grogan, JL;McKerrow, JH
通讯作者：
McKerrow, JH
影响因子：
11.4
作者：
Oenal, Pinar;Gruen, Dominic;Rajewsky, Nikolaus
通讯作者：
Rajewsky, Nikolaus
影响因子：
5.2
作者：
Labbe, Roselyne M.;Irimia, Manuel;Currie, Ko W.;Lin, Alexander;Zhu, Shu Jun;Brown, David D. R.;Ross, Eric J.;Voisin, Veronique;Bader, Gary D.;Blencowe, Benjamin J.;Pearson, Bret J.
通讯作者：
Pearson, Bret J.
影响因子：
2.4
作者：
Brehm, K.
通讯作者：
Brehm, K.