Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents.
Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents.
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DOI：
10.1016/j.clim.2021.108912
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Kennedy RB
中科院分区：
文献类型：
--
作者：
Riggenbach MM;Haralambieva IH;Ovsyannikova IG;Schaid DJ;Poland GA;Kennedy RB
尽管MMR-II在美国的使用率很高，但腮腺炎疫情仍在继续发生。有证据表明，腮腺炎疫苗诱导的体液免疫会随着时间的推移而减弱。相对较少的研究检查了细胞介导的免疫或报道了基于性别的差异。为了更好地了解腮腺炎疫苗免疫反应的性别差异，我们测量了748名青少年和年轻人在接种两剂MMR疫苗后的中和抗体效价和腮腺炎特异性细胞因子/趋化因子反应。女性血清中和抗体滴度显著高于男性(120.8 IU/mL，98.7IU/mL，p=0.038)，而男性的MIP-1α、MIP-1β、肿瘤坏死因子α、IL-6、干扰素γ和IL-1β的分泌水平显著高于女性。这些数据表明，性别影响腮腺炎特异性体液和细胞介导的免疫反应结果，这一现象应该在努力改进疫苗和防止未来爆发时考虑到。
Despite high levels of MMR-II usage in the US, mumps outbreaks continue to occur. Evidence suggests that mumps vaccine-induced humoral immunity wanes over time. Relatively few studies have examined cell-mediated immunity or reported on sex-based differences. To better understand sex-based differences in the immune response to mumps vaccine, we measured neutralizing antibody titers and mumps-specific cytokine/chemokine responses in a cohort of 748 adolescents and young adults after two doses of MMR vaccine. We observed significantly higher neutralizing antibody titers in females than in males (120.8 IU/mL, 98.7IU/mL, p=0.038) but significantly higher secretion levels of MIP-1α, MIP-1β, TNFα, IL-6, IFNγ, and IL-1β in males compared to females. These data demonstrate that sex influences mumps-specific humoral and cell-mediated immune response outcomes, a phenomenon that should be considered during efforts to improve vaccines and prevent future outbreaks.
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影响因子：
3.2
作者：
Dhiman, Neelam;Haralambieva, Iana H.;Kennedy, Richard B.;Vierkant, Robert A.;O'Byrne, Megan M.;Ovsyannikova, Inna G.;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
CD46 和 IFI44L 基因变异与麻疹疫苗中和抗体反应的全基因组关联。
影响因子：
5.3
作者：
Haralambieva IH;Ovsyannikova IG;Kennedy RB;Larrabee BR;Zimmermann MT;Grill DE;Schaid DJ;Poland GA
通讯作者：
Poland GA
影响因子：
5.3
作者：
Kennedy, Richard B.;Ovsyannikova, Inna G.;Haralambieva, Iana H.;Lambert, Nathaniel D.;Pankratz, V. Shane;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
--
作者：
Dhiman, N.;Ovsyannikova, G.;Poland, G. A.
通讯作者：
Poland, G. A.
影响因子：
6.4
作者：
Jokinen, Sari;Osterlund, Pamela;Davidkin, Irja
通讯作者：
Davidkin, Irja