Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation.
Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation.
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DOI：
10.1007/s00213-010-2038-x
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Nader, Michael A.
中科院分区：
文献类型：
--
作者：
Hamilton, Lindsey R.;Czoty, Paul W.;Nader, Michael A.
关键词：
在子宫内，可卡因暴露与猴子多巴胺（DA）系统的改变有关。然而，产前可卡因暴露在成年期的行为结果却知之甚少。评估14岁恒河猴在子宫内和对照组（每组10只）暴露于可卡因的几项行为指标。在这些研究中，研究了两个非条件行为任务，新物体反应性和运动活动，以及两个条件行为任务，反应消退和延迟折扣。此外，对脑脊液（CSF）样本进行单胺代谢物高香草酸（HVA）和5-羟基吲哚乙酸（5-HIAA）的浓度分析。脑脊液5-HIAA和HVA浓度、接触新物体的潜伏期或运动活动测量在组间或性别间均无差异。然而，与对照猴子相比，产前暴露于可卡因的猴子需要明显更多的会话来达到食物强化行为灭绝的标准。在延迟-折扣任务上，在较短的延迟值下，可卡因暴露雄猴比对照雄猴更倾向于从较大的强化物转向较小的强化物；在女性中没有观察到差异。这些发现表明，产前可卡因暴露会导致受性别影响的长期神经行为缺陷。
In utero cocaine exposure has been associated with alterations in the dopamine (DA) system in monkeys. However, the behavioral outcomes of prenatal cocaine exposure in adulthood are poorly understood. To assess several behavioral measures in 14-year-old rhesus monkeys exposed to cocaine in utero and controls (n=10 per group). For these studies, two unconditioned behavioral tasks, novel object reactivity and locomotor activity, and two conditioned behavioral tasks, response extinction and delay discounting, were examined. In addition, cerebrospinal fluid (CSF) samples were analyzed for concentrations of the monoamine metabolites homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA). No differences in CSF concentrations of 5-HIAA and HVA, latencies to touch a novel object or locomotor activity measures were observed between groups or sexes. However, prenatally cocaine-exposed monkeys required a significantly greater number of sessions to reach criteria for extinction of food-reinforced behavior than control monkeys. On the delay-discounting task, male prenatally cocaine-exposed monkeys switched preference from the larger reinforcer to the smaller one at shorter delay values than male control monkeys; no differences were observed in females. These findings suggest that prenatal cocaine exposure results in long-term neurobehavioral deficits that are influenced by sex of the individual.
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影响因子：
3.4
作者：
Hamilton, Lindsey R.;Czoty, Paul W.;Gage, H. Donald;Nader, Michael A.
通讯作者：
Nader, Michael A.
影响因子：
10.6
作者：
Higley, JD;Mehlman, PT;Linnoila, M
通讯作者：
Linnoila, M
影响因子：
7.6
作者：
Czoty, Paul W.;Riddick, Natallia V.;Nader, Michael A.
通讯作者：
Nader, Michael A.
影响因子：
2.4
作者：
Fairbanks, LA;Jorgensen, MJ;Mann, JJ
通讯作者：
Mann, JJ
影响因子：
2.5
作者：
BOLIG, R;PRICE, CS;SUOMI, SJ
通讯作者：
SUOMI, SJ