Resilience integrates concepts in aging research.
Resilience integrates concepts in aging research.
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DOI：
10.1016/j.isci.2022.104199
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发表时间：
2022-05-20
期刊：
影响因子：
5.8
通讯作者：
Hochberg, Michael E.
中科院分区：
文献类型：
--
作者：
Promislow, Daniel;Anderson, Rozalyn M.;Scheffer, Marten;Crespi, Bernard;DeGregori, James;Harris, Kelley;Horowitz, Barbara Natterson;Levine, Morgan E.;Riolo, Maria A.;Schneider, David S.;Spencer, Sabrina L.;Valenzano, Dario Riccardo;Hochberg, Michael E.
衰老研究所涵盖的学科范围是无与伦比的，从研究塑造衰老的力量的进化研究到揭示与年龄相关的功能衰退的潜在机制的分子研究。尽管有一个共同的焦点，以促进我们对老龄化的理解，这些学科已经进行了沿着不同的道路，几乎没有串扰。我们认为，韧性的概念可以弥合这一差距。弹性描述了系统通过返回到其原始状态来响应扰动的能力。虽然复原力已被应用于衰老研究中的一些学科，如脆弱和认知衰退，但它还没有被探索为一个统一的概念框架，能够连接不同的研究领域。我们认为，由于基于行为的框架可以跨越广泛的生理水平和时间尺度，它可以提供连接这些不同学科的缺失环节。由此产生的框架将促进预测建模和验证，并影响衰老生物学研究的目标和方向。健康科学;生物科学;分子生物学;进化生物学;细胞生物学
Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging. Health sciences; Biological sciences; Molecular biology; Evolutionary biology; Cell biology
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