Migrations of cancer cells through the lens of phylogenetic biogeography.
Migrations of cancer cells through the lens of phylogenetic biogeography.
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DOI：
10.1038/s41598-021-96215-9
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发表时间：
2021-08-25
影响因子：
4.6
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Chroni A;Miura S;Oladeinde O;Aly V;Kumar S
恶性肿瘤细胞离开其最初生长的肿瘤并分散到其他组织形成转移。当种群中的个体从其原产地迁移到其他栖息地时，扩散也会发生在自然界中。在癌症中，系统发育生物地理学关注细胞运动的来源和轨迹。我们研究了有机体生物地理学的主要特征（包括遗传多样性、扩散、灭绝、替代性和奠基者效应）的适用性，以描述和重建肿瘤之间的克隆迁移事件。我们使用计算机模拟数据来比较七个生物地理模型的拟合度，并评估模型在克隆迁移重建中的性能。考虑创始人效应和扩散的模型通常更适合克隆系统发育模式，尤其是多克隆播种和转移的重新播种。然而，更简单的生物地理模型可以更准确地估计细胞迁移历史。对基底样乳腺癌经验数据集的分析具有与计算机模拟数据集分析中看到的模式一致的模型拟合。我们的分析揭示了使用肿瘤基因组变异数据建模和推断克隆迁移历史的生物地理学模型的力量和缺陷。我们的结论是，分子进化和生物地理学的原理在这些努力中是有用的，但需要明智地应用可用的模型和方法。
Malignant cells leave their initial tumor of growth and disperse to other tissues to form metastases. Dispersals also occur in nature when individuals in a population migrate from their area of origin to colonize other habitats. In cancer, phylogenetic biogeography is concerned with the source and trajectory of cell movements. We examine the suitability of primary features of organismal biogeography, including genetic diversification, dispersal, extinction, vicariance, and founder effects, to describe and reconstruct clone migration events among tumors. We used computer-simulated data to compare fits of seven biogeographic models and evaluate models’ performance in clone migration reconstruction. Models considering founder effects and dispersals were often better fit for the clone phylogenetic patterns, especially for polyclonal seeding and reseeding of metastases. However, simpler biogeographic models produced more accurate estimates of cell migration histories. Analyses of empirical datasets of basal-like breast cancer had model fits consistent with the patterns seen in the analysis of computer-simulated datasets. Our analyses reveal the powers and pitfalls of biogeographic models for modeling and inferring clone migration histories using tumor genome variation data. We conclude that the principles of molecular evolution and organismal biogeography are useful in these endeavors but that the available models and methods need to be applied judiciously.
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DOI：
10.1126/science.abc1944
发表时间：
2021-02-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Quinn JJ;Jones MG;Okimoto RA;Nanjo S;Chan MM;Yosef N;Bivona TG;Weissman JS
通讯作者：
Weissman JS
影响因子：
6.5
作者：
Ree, Richard H.;Smith, Stephen A.
通讯作者：
Smith, Stephen A.
影响因子：
5.2
作者：
Chroni, Antonia;Vu, Tracy;Kumar, Sudhir
通讯作者：
Kumar, Sudhir
影响因子：
10.7
作者：
Somarelli, Jason A.;Gardner, Heather;Townsend, Jeffrey P.
通讯作者：
Townsend, Jeffrey P.
影响因子：
64.5
作者：
Turajlic S;Xu H;Litchfield K;Rowan A;Chambers T;Lopez JI;Nicol D;O'Brien T;Larkin J;Horswell S;Stares M;Au L;Jamal-Hanjani M;Challacombe B;Chandra A;Hazell S;Eichler-Jonsson C;Soultati A;Chowdhury S;Rudman S;Lynch J;Fernando A;Stamp G;Nye E;Jabbar F;Spain L;Lall S;Guarch R;Falzon M;Proctor I;Pickering L;Gore M;Watkins TBK;Ward S;Stewart A;DiNatale R;Becerra MF;Reznik E;Hsieh JJ;Richmond TA;Mayhew GF;Hill SM;McNally CD;Jones C;Rosenbaum H;Stanislaw S;Burgess DL;Alexander NR;Swanton C;PEACE;TRACERx Renal Consortium
通讯作者：
TRACERx Renal Consortium