Feed- and feed additives-related aspects of gut health and development in weanling pigs.
Feed- and feed additives-related aspects of gut health and development in weanling pigs.
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DOI：
10.1186/2049-1891-4-1
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发表时间：
2013-01-07
影响因子：
7
通讯作者：
Pluske JR
中科院分区：
文献类型：
--
作者：
Pluske JR
开发新的/不同的管理和饲养策略，以刺激新断奶猪的肠道发育和健康，以改善生长性能，同时最大限度地减少抗生素生长促进剂(AGP)和重矿物化合物等抗菌化合物的使用，对于养猪业的长期可持续性至关重要。包括营养和能量摄入不足、微生物区系生物量和(或)平衡不适当、免疫功能不成熟和受损以及断奶引起的心身因素等因素都会通过粘膜损伤和紧密连接完整性的改变而损害消化吸收效率和肠道屏障功能。因此，断奶仔猪对致病性肠道疾病高度敏感，例如可能由产肠毒素大肠杆菌血清型引起的断奶后腹泻。已知许多日粮成分，如蛋白质、纤维、饲料添加剂和矿物质，会影响胃肠道微生物的生长，进而影响猪的生长和健康，尽管这些之间的关系有时并不一定明显或明显。在养猪生产中对抗生素本身的使用进行更严格审查的世界气候下，某些饲料添加剂被视为抗生素的替代品/替代品，并在某些情况下演变为在日常商业猪营养中发挥重要作用。然而，总的来说，一些饲料添加剂的效果仍然不一致和多变，在严重疾病暴发的情况下，通常依赖治疗性抗生素和/或氧化锌(ZnO)等重矿物。如果饲料成分和(或)饲料添加剂的使用更加规律性和可靠性，那么有必要结合使用适当的挑战模型和体外和体内技术，更好地了解抗生素和矿物质(如氧化锌)影响动物生理的机制。
The development of new/different management and feeding strategies to stimulate gut development and health in newly-weaned pigs, in order to improve growth performance while minimizing the use of antimicrobial compounds such as antibiotic growth promotants (AGP) and heavy mineral compounds, is essential for the long-term sustainability of the pig industry. Factors including the sub-optimal intake of nutrients and energy, inappropriate microbiota biomass and (or) balance, immature and compromised immune function, and psychosomatic factors caused by weaning can compromise both the efficiency of digestion and absorption and intestinal barrier function through mucosal damage and alteration of tight junction integrity. As a consequence, pigs at weaning are highly susceptible to pathogenic enteric conditions such as post-weaning diarrhea that may be caused by serotypes of enterotoxigenic Escherichia coli. Many dietary components, e.g., protein, fiber, feed additives and minerals, are known to influence microbial growth in the gastrointestinal tract that in turn can impact upon pig growth and health, although the relationships between these are sometimes not necessarily apparent or obvious. In a world climate of increased scrutiny over the use of antibiotics per se in pig production, certain feed additives are seen as alternatives/replacements to antibiotics, and have evolved in some cases to have important roles in everyday commercial pig nutrition. Nevertheless and in general, there remains inconsistency and variability in the efficacy of some feed additives and in cases of severe disease outbreaks, for example, therapeutic antibiotics and/or heavy minerals such as zinc oxide (ZnO) are generally relied upon. If feed ingredients and (or) feed additives are to be used with greater regularity and reliability, then it is necessary to better understand the mechanisms whereby antibiotics and minerals such as ZnO influence animal physiology, in conjunction with the use of appropriate challenge models and in vitro and in vivo techniques.
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影响因子：
3.3
作者：
Smith, M. G.;Jordan, D.;Trott, D. J.
通讯作者：
Trott, D. J.
影响因子：
3.6
作者：
Kim, Jae Cheol;Mullan, Bruce P.;Pluske, John R.
通讯作者：
Pluske, John R.
DOI：
10.1111/j.1467-8276.2006.00913.x
发表时间：
2006-11-01
影响因子：
4.2
作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
4
作者：
Si, W;Gong, J;Du, Z
通讯作者：
Du, Z