Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.

Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 'high definition' neuroimaging.
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DOI:
10.1016/j.conb.2014.08.005
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发表时间:
2015-02
影响因子:
5.7
通讯作者:
Castellanos FX
Castellanos FX
中科院分区:
医学2区
文献类型:
--
作者:
Baroni A;Castellanos FX

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人类连接组项目(HCP)数据的持续发布是临床神经科学领域的一个分水岭事件。通过在双胞胎/兄弟姐妹设计框架内实现空间和时间分辨率的巨大飞跃,这一开放科学资源为描绘神经精神领域的脑 - 行为关系提供了基础。在此,我们关注注意缺陷/多动障碍(ADHD),它在人群中至少部分是连续的,重点介绍针对ADHD提出的且包含在HCP表型组中的构想。我们回顾了与ADHD相关的构想(与奖励相关的处理、抑制、警觉性注意、反应时间变异性、计时和情绪不稳定性),这些构想可在HCP数据以及未来的“高分辨率”临床数据集中进行研究。
The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future “high definition” clinical datasets.
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发表时间: 2013-06
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影响因子: 48
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