Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory.
Level of intrauterine cocaine exposure and neuropsychological test scores in preadolescence: subtle effects on auditory attention and narrative memory.
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DOI：
10.1016/j.ntt.2014.06.007
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发表时间：
2014-09
影响因子：
2.9
通讯作者：
Frank, Deborah A.
中科院分区：
文献类型：
--
作者：
Beeghly, Marjorie;Rose-Jacobs, Ruth;Martin, Brett M.;Cabral, Howard J.;Heeren, Timothy C.;Frank, Deborah A.
关键词：
注意力和记忆等神经心理过程有助于儿童更高水平的认知和语言功能，并预测学业成就。本分析的目的是在控制相关变量后，评估宫内可卡因暴露（IUCE）水平是否会改变青春期前神经心理功能的多个方面，使用单一年龄参考工具，即发育神经心理评估（NEPSY）进行评估。参与者包括来自正在进行的前瞻性纵向研究的137名来自低收入城市背景的9.5岁儿童（51%为男性，90%为非洲裔美国人/加勒比人）。采用新生儿胎便和产妇报告评估新生儿IUCE水平。52%的儿童有IUCE(65%为较轻的IUCE， 35%为较重的IUCE)， 48%未暴露。排除了患有胎儿酒精综合症、艾滋病毒血清阳性或宫内暴露于可卡因和大麻以外的非法物质的婴儿。在9.5年的随访中，训练有素的审查员掩盖了IUCE和背景变量，使用NEPSY评估儿童的神经心理功能。通过控制宫内暴露于其他物质和相关儿童、照顾者和人口变量的一系列线性回归，评估IUCE水平和新生儿新生儿新生儿睡眠质量结局之间的关系。结果表明，IUCE水平与听觉注意和叙事记忆任务得分较低相关，这两项任务都需要听觉信息处理和持续注意力才能成功完成。然而，结果并不符合预期的顺序，剂量依赖模式。儿童的神经心理测试分数也会受到其他各种生物和社会心理因素的影响。
Neuropsychological processes such as attention and memory contribute to children's higher-level cognitive and language functioning and predict academic achievement. The goal of this analysis was to evaluate whether level of intrauterine cocaine exposure (IUCE) alters multiple aspects of preadolescents' neuropsychological functioning assessed using a single age-referenced instrument, the NEPSY: A Developmental Neuropsychological Assessment (NEPSY), after controlling for relevant covariates. Participants included 137 term 9.5-year-old children from low-income urban backgrounds (51% male, 90% African American/Caribbean) from an ongoing prospective longitudinal study. Level of IUCE was assessed in the newborn period using infant meconium and maternal report. 52% of the children had IUCE (65% with lighter IUCE, and 35% with heavier IUCE), and 48% were unexposed. Infants with Fetal Alcohol Syndrome, HIV seropositivity, or intrauterine exposure to illicit substances other than cocaine and marijuana were excluded. At the 9.5-year follow-up visit, trained examiners masked to IUCE and background variables evaluated children's neuropsychological functioning using the NEPSY. The association between level of IUCE and NEPSY outcomes was evaluated in a series of linear regressions controlling for intrauterine exposure to other substances and relevant child, caregiver, and demographic variables. Results indicated that level of IUCE was associated with lower scores on the Auditory Attention and Narrative Memory tasks, both of which require auditory information processing and sustained attention for successful performance. However, results did not follow the expected ordinal, dose-dependent pattern. Children's neuropsychological test scores were also altered by a variety of other biological and psychosocial factors.
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影响因子：
4
作者：
Alessandri, SM;Bendersky, M;Lewis, M
通讯作者：
Lewis, M
DOI：
10.1097/00004703-200404000-00002
发表时间：
2004-04-01
影响因子：
2.4
作者：
Arendt, RE;Short, EJ;Flannery, D
通讯作者：
Flannery, D
影响因子：
2.9
作者：
Betancourt, Laura M.;Yang, Wei;Hurt, Hallam
通讯作者：
Hurt, Hallam
影响因子：
2.2
作者：
Burchinal, Margaret;Roberts, Joanne E.;Hooper, Stephen
通讯作者：
Hooper, Stephen
影响因子：
3.5
作者：
Ben-Yehudah, Gal;Guediche, Sara;Fiez, Julie A.
通讯作者：
Fiez, Julie A.