Metabolomics in Bone Research.
Metabolomics in Bone Research.
复制标题
骨研究中的代谢组学。
DOI：
10.3390/metabo11070434
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发表时间：
2021-07-01
期刊：
影响因子：
4.1
通讯作者：
Klavins K
中科院分区：
文献类型：
--
作者：
Fan J;Jahed V;Klavins K
识别内源性代谢物响应于内在和外在因素的变化具有极好的潜力，以获得对细胞、生物流体、组织或生物体的功能以及与环境的相互作用的理解。代谢组学策略所提供的优势促进了骨研究领域的研究，包括对骨细胞行为的理解、疾病的诊断和预后以及治疗方法（如植入生物材料）的开发。本文综述了硬组织成骨、破骨细胞生成和免疫调节过程中的代谢变化。本综述的第二部分致力于描述和讨论最相关的骨疾病：骨质疏松症，骨损伤，类风湿性关节炎和骨肉瘤中的代谢物变化。我们巩固了最新发现的代谢物和代谢途径受各种骨疾病。这些数据可以作为未来代谢组学驱动的骨骼研究的基础，以选择最相关的代谢物和代谢途径。此外，我们还总结了代谢组学的最新研究成果，为骨疾病的治疗，包括骨工程生物材料的发展。通过这篇文章，我们的目的是提供一个全面的总结代谢组学在骨研究，这可以帮助跨学科的研究人员，包括材料工程师，生物学家和临床医生。
Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or organisms’ functions and interactions with the environment. The advantages provided by the metabolomics strategy have promoted studies in bone research fields, including an understanding of bone cell behaviors, diagnosis and prognosis of diseases, and the development of treatment methods such as implanted biomaterials. This review article summarizes the metabolism changes during osteogenesis, osteoclastogenesis, and immunoregulation in hard tissue. The second section of this review is dedicated to describing and discussing metabolite changes in the most relevant bone diseases: osteoporosis, bone injuries, rheumatoid arthritis, and osteosarcoma. We consolidated the most recent finding of the metabolites and metabolite pathways affected by various bone disorders. This collection can serve as a basis for future metabolomics-driven bone research studies to select the most relevant metabolites and metabolic pathways. Additionally, we summarize recent metabolic studies on metabolomics for the development of bone disease treatment including biomaterials for bone engineering. With this article, we aim to provide a comprehensive summary of metabolomics in bone research, which can be helpful for interdisciplinary researchers, including material engineers, biologists, and clinicians.
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