MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets.
MicroSNiPer: a web tool for prediction of SNP effects on putative microRNA targets.
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DOI：
10.1002/humu.21349
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发表时间：
2010-11
期刊：
影响因子：
3.9
通讯作者：
Weinberger, Daniel R.
中科院分区：
文献类型：
--
作者：
Barenboim, Maxim;Zoltick, Brad J.;Guo, Yongjian;Weinberger, Daniel R.
MicroRNA 是短的、大约 22 个核苷酸的非编码 RNA，与目标 mRNA 3'UTR 中的部分互补位点结合。这个过程通常会导致特定 microRNA 抑制多个靶标。鉴于 microRNA 对转录后调控的影响及其与复杂疾病的潜在关系，人们对旨在预测 microRNA 靶标以及单核苷酸多态性 (SNP) 对 microRNA 结合的影响的方法产生了浓厚的兴趣。我们开发了一个基于网络的应用程序 MicroSNiPer，它可以预测 SNP 对假定的 microRNA 目标的影响。该应用询问 3'-非翻译区域并预测目标位点内的 SNP 是否会破坏/消除或增强/创建 microRNA 结合位点。 MicroSNiPer 计算这些位点并实时检查 SNP 的影响。 MicroSNiPer 是一个用户友好的基于网络的工具。其优点包括易用性、灵活性和结果的直观图形表示。可通过 http://cbdb.nimh.nih.gov/microsniper 免费访问。
MicroRNAs are short, approximately 22 nucleotide non-coding RNAs binding to partially complementary sites in the 3'UTR of target mRNAs. This process generally results in repression of multiple targets by a particular microRNA. There is substantial interest in methods designed to predict the microRNA targets and effect of single nucleotide polymorphisms (SNPs) on microRNA binding, given the impact of microRNA on posttranscriptional regulation and its potential relation to complex diseases. We developed a web-based application, MicroSNiPer, which predicts the impact of a SNP on putative microRNA targets. This application interrogates the 3'-untranslated region and predicts if a SNP within the target site will disrupt/eliminate or enhance/create a microRNA binding site. MicroSNiPer computes these sites and examines the effects of SNPs in real time. MicroSNiPer is a user-friendly web-based tool. Its advantages include ease of use, flexibility and straightforward graphical representation of the results. It is freely accessible at http://cbdb.nimh.nih.gov/microsniper.
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通讯作者：
Skol, Andrew
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