Robustness of sex-differences in functional connectivity over time in middle-aged marmosets.
Robustness of sex-differences in functional connectivity over time in middle-aged marmosets.
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DOI：
10.1038/s41598-020-73811-9
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发表时间：
2020-10-06
影响因子：
4.6
通讯作者：
Lacreuse A
中科院分区：
文献类型：
--
作者：
Nephew BC;Febo M;Cali R;Workman KP;Payne L;Moore CM;King JA;Lacreuse A
非人类灵长类动物 (NHP) 是全面了解人类神经认知衰老的神经机制的重要研究模型。在本研究中，我们使用静息态功能连接 (rsFC) 来研究未麻醉的普通狨猴 (Callithrix jacchus) 在中年后期的两个时间点（相隔 8 个月，类似于人类 5-6 年的时间点）前额皮质和纹状体神经相互作用与认知灵活性之间的关系。根据我们之前的发现，我们还确定了 8 个月内连接测量的可重复性，特别是之前观察到的 rsFC 中的性别差异。雄性狨猴表现出与雌性狨猴非常相似的模式，即相对于雌性狨猴具有更强的功能连接性，并且在两个成像时间点之间具有更大的认知灵活性。网络分析显示，与女性相比，男性在连接性和相关认知关联方面存在一致的性别差异，其特征是前额叶、运动前和颞叶区域的节点强度和/或程度值更大，以及 PFC 内的连接性更强。目前的研究支持前额叶和纹状体静息状态网络中存在显着的性别差异，这可能导致认知功能的差异，并提供了对可能在认知衰老和年龄相关疾病（如轻度认知障碍和阿尔茨海默病）中受损的神经系统的见解。
Nonhuman primates (NHPs) are an essential research model for gaining a comprehensive understanding of the neural mechanisms of neurocognitive aging in our own species. In the present study, we used resting state functional connectivity (rsFC) to investigate the relationship between prefrontal cortical and striatal neural interactions, and cognitive flexibility, in unanaesthetized common marmosets (Callithrix jacchus) at two time points during late middle age (8 months apart, similar to a span of 5–6 years in humans). Based on our previous findings, we also determine the reproducibility of connectivity measures over the course of 8 months, particularly previously observed sex differences in rsFC. Male marmosets exhibited remarkably similar patterns of stronger functional connectivity relative to females and greater cognitive flexibility between the two imaging time points. Network analysis revealed that the consistent sex differences in connectivity and related cognitive associations were characterized by greater node strength and/or degree values in several prefrontal, premotor and temporal regions, as well as stronger intra PFC connectivity, in males compared to females. The current study supports the existence of robust sex differences in prefrontal and striatal resting state networks that may contribute to differences in cognitive function and offers insight on the neural systems that may be compromised in cognitive aging and age-related conditions such as mild cognitive impairment and Alzheimer’s disease.
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