Interactions of Candida albicans with epithelial cells.
Interactions of Candida albicans with epithelial cells.
复制标题
DOI：
10.1111/j.1462-5822.2009.01412.x
复制
发表时间：
2010-03
影响因子：
3.4
通讯作者：
Filler SG
中科院分区：
文献类型：
--
作者：
Zhu W;Filler SG
真菌，白色念珠菌与人类宿主的上皮细胞相互作用，既作为正常的寄生虫，也作为侵入性病原体。它已经进化出多种互补机制来粘附上皮细胞。附着C.白色念珠菌细胞可以通过渗透到单个上皮细胞中以及通过降解上皮细胞间连接和在上皮细胞之间通过而侵入上皮表面。上皮细胞的侵入是由诱导的内吞作用和主动渗透介导的，而上皮细胞连接蛋白（如E-钙粘蛋白）的降解主要通过分泌型乙酰基蛋白酶的蛋白水解发生。C.白色念珠菌对上皮细胞的侵袭导致显著的上皮细胞损伤，这可能是由生物体分泌的裂解酶如蛋白酶和磷脂酶诱导的。未来的挑战包括识别粘附素和侵袭素的上皮细胞靶点，以及确定C。白色念珠菌主动穿透上皮细胞并诱导上皮细胞损伤。
The fungus, Candida albicans interacts with epithelial cells in the human host both as a normal commensal and as an invasive pathogen. It has evolved multiple complementary mechanisms to adhere to epithelial cells. Adherent C. albicans cells can invade epithelial surfaces both by penetrating into individual epithelial cells, and by degrading inter-epithelial cell junctions and passing between epithelial cells. Invasion into epithelial cells is mediated by both induced endocytosis and active penetration, whereas degradation of epithelial cell junction proteins, such as E-cadherin occurs mainly via proteolysis by secreted aspartyl proteinases. C. albicans invasion of epithelial cells results in significant epithelial cell damage, which is probably induced by lytic enzymes, such as proteases and phospholipase secreted by the organism. Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage.
登录
查看更多内容
影响因子：
5.8
作者：
Kempf, Marie;Apaire-Marchais, Veronique;Cottin, Jane
通讯作者：
Cottin, Jane
影响因子：
3.1
作者：
Bates, Steven;de la Rosa, Jose M.;Odds, Frank C.
通讯作者：
Odds, Frank C.
影响因子：
2.8
作者：
Granger, BL;Flenniken, ML;Cutler, JE
通讯作者：
Cutler, JE
影响因子：
2.6
作者：
Alberti-Segui, C;Morales, AJ;Rogers, B
通讯作者：
Rogers, B
影响因子：
6.4
作者：
De Bernardis, F;Arancia, S;Cassone, A
通讯作者：
Cassone, A