Alcohol consumption and serum hormone levels during pregnancy.
Alcohol consumption and serum hormone levels during pregnancy.
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怀孕期间的饮酒量和血清激素水平。
DOI：
10.1016/j.alcohol.2005.07.006
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Cohn,BarbaraA
中科院分区：
文献类型：
--
作者：
Stevens,RichardG;Cohen,RichardD;Terry,MaryBeth;Lasley,BillL;Siiteri,Pentti;Cohn,BarbaraA
怀孕期间改变性激素水平的因素可能会对后代产生长期的健康影响，包括乳腺癌风险的变化。对从儿童健康与发育研究队列中抽取的339名孕妇进行了酒精消费和激素水平的横断面分析。酒精摄入量从1959年到1966年进行了调查，早在怀孕期间饮酒的危害被公布之前。分析孕晚期血清激素水平，包括雌二醇和睾酮。在339名孕妇中，有196人报告在怀孕期间饮酒。饮酒者被分为三组，每周摄入0.2-0.5，0.6-2.0和2.1-12.5盎司的乙醇。第二组对应于每周饮酒量的中位数为102杯，最后一组对应于每天饮酒量的中位数为101杯，这被认为是“轻度”至“中度”饮酒。母亲雌二醇水平与怀孕期间饮酒无关。然而，后两组饮酒孕妇的血清睾酮显著降低，分别为12.2%[置信区间（CI）=-3.0至25.2]和25.6%（CI=9.2-39.5）。报告的酒精摄入量远远低于导致胎儿酒精综合征的摄入量，或迄今为止研究的任何胎儿酒精影响。怀孕期间少量饮酒与母体睾酮水平较低有关。对健康的影响尚不确定，但可能包括饮酒母亲的女儿乳房密度增加。
Factors that change sex hormone levels during pregnancy may have long-term health consequences for the offspring, including changes in breast cancer risk. A cross-sectional analysis of alcohol consumption and hormone levels in 339 pregnant women sampled from the Child Health and Development Study cohort was undertaken. Alcohol intake was queried from 1959 to 1966, long before any hazards of drinking during pregnancy were publicized. Third trimester serum hormone levels including estradiol and testosterone were analyzed. Among 339 pregnant women, 196 reported some alcohol consumption during pregnancy. The drinkers were divided into three groups with intake levels of 0.2–0.5, 0.6–2.0, and 2.1–12.5 ounces of ethanol per week. The second group corresponds to a median intake of ∼2 drinks per week, and the last group corresponds to a median intake of ∼1 drink per day, which is considered “light” to “moderate” drinking. Maternal estradiol levels were not associated with alcohol intake during pregnancy. However, serum testosterone was significantly lower, by 12.2%, in the latter two groups of drinking pregnant women, [confidence interval (CI)=−3.0 to 25.2] and 25.6% (CI=9.2–39.5), respectively. The alcohol intakes reported are far below those shown to cause fetal alcohol syndrome, or any of the fetal alcohol effects so far studied. Light alcohol intake during pregnancy is associated with lower maternal testosterone. The health implications are uncertain, but may include an increased breast density in the daughters of drinking mothers.
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