Fasting plasma glucose and variation in cardiometabolic risk factors in people with high-risk HbA1c-defined prediabetes: A cross-sectional multiethnic study.
Fasting plasma glucose and variation in cardiometabolic risk factors in people with high-risk HbA1c-defined prediabetes: A cross-sectional multiethnic study.
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高危 HbA1c 定义的糖尿病前期人群的空腹血糖和心脏代谢危险因素的变化：一项横断面多种族研究。
DOI：
10.1016/j.diabres.2017.10.017
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发表时间：
2017
影响因子：
5.1
通讯作者：
Srivanichakorn W
中科院分区：
文献类型：
--
作者：
Srivanichakorn W
目的：前驱糖尿病患者心脏代谢风险的变化以及种族对这种变化的影响研究甚少。在一个种族多样化的数据集中，根据基于高危hba1c的糖尿病前期定义选择，我们研究了血糖和心脏代谢危险因素之间的关系以及种族对这些关系的影响。方法：我们对来自英国糖尿病预防研究和泰国慢性护理诊所的基线数据进行了横断面分析，选择了无糖尿病（空腹血糖<7.0 mmol/l）、HbA1c 6.0-6.4% （42-47 mmol/mol）的人群。区分泰国（n = 158）、英国白种人（n = 600）、南亚（n = 112）、黑人（n = 70）和其他/混合（n = 103）组，测量包括空腹血糖（FPG）、血压（BP）、血脂和胰岛素抵抗相关危险因素（irf）。结果独立于包括种族在内的个体特征，只有收缩压与FPG （β系数1.76 (95%CI 0.10-3.42), p 0.03）弱相关，只有LDL-c与IFG (FPG 5.6至<7)（调整为- 0.14 (- 0.27,- 0.003)p 0.04）弱相关。当考虑空腹血糖受损（FPG≥6.1至<7.0 mmol/L）的类别时，与心脏代谢危险因素没有显著的独立关联。相对于白人，南亚种族与较低的收缩压和舒张压独立相关，黑人与较低的甘油三酯，胆固醇/HDL-c比率和2个或更多的irf相关，泰国人与较低的胆固醇/HDL-c比率相关，所有三个非白人种族与较低的总胆固醇和低密度脂蛋白胆固醇相关。结论：在hba1c定义的高危糖尿病前期，额外测量FPG对评估心脏代谢风险的作用不大。此外，英国白人的心脏代谢状况往往是所有种族中最不利的。
AimsVariation in cardiometabolic risk in prediabetes and any impacts of ethnicity on such variation have been little studied. In an ethnically diverse dataset, selected according to a high-risk HbA1c-based definition of prediabetes, we have investigated relationships between glycaemia and cardiometabolic risk factors and the influence of ethnicity on these relationships.MethodsWe undertook a cross-sectional analysis of baseline data from a diabetes prevention study in the UK and a chronic care clinic in Thailand, selected for people without diabetes (fasting plasma glucose <7.0 mmol/l) with HbA1c 6.0–6.4% (42–47 mmol/mol). Thai (n = 158) and UK White (n = 600), South Asian (n = 112), Black (n = 70) and other/mixed (n = 103) groups were distinguished and measurements included fasting plasma glucose (FPG), blood pressure (BP), lipids and insulin resistance-related risk factors (IRFs).ResultsIndependently of individual characteristics including ethnicity, only systolic BP was weakly associated with FPG (beta coefficient 1.76 (95%CI 0.10–3.42), p 0.03) and only LDL-c with IFG (FPG 5.6 to <7) (adjusted −0.14 (−0.27, −0.003) p 0.04). There were no significant independent associations with cardiometabolic risk factors when categories of impaired fasting glucose (FPG ≥ 6.1 to <7.0 mmol/L) were considered. Relative to White, South Asian ethnicity was independently associated with lower systolic and diastolic BP, Black with lower triglycerides, cholesterol/HDL-c ratio and having 2 or more IRFs, and Thai with lower cholesterol/HDL-c ratio and all three non-white ethnicities with lower total and LDL cholesterol.ConclusionIn high-risk HbA1c-defined prediabetes additional measurement of FPG will add little to evaluation of cardiometabolic risk. Additionally, UK Whites tend to have the most adverse cardiometabolic profile of any ethnic group.
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影响因子：
44.5
作者：
Warren, Bethany;Pankow, James S.;Matsushita, Kunihiro;Punjabi, Naresh M.;Daya, Natalie R.;Grams, Morgan;Woodward, Mark;Selvin, Elizabeth
通讯作者：
Selvin, Elizabeth
糖血红蛋白的个体内变异：对解释和分析目标的影响。
影响因子：
9.3
作者：
G. Phillipou;P. Phillips
通讯作者：
P. Phillips
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
HbA1c 单独作为中年糖尿病前期受试者的心脏代谢风险指标很差，但适合 2 型糖尿病诊断：一项横断面研究
影响因子：
3.7
作者：
S. Millar;I. Perry;C. Phillips
通讯作者：
C. Phillips
影响因子：
168.9
作者：
Heianza, Yoriko;Hara, Shigeko;Sone, Hirohito
通讯作者：
Sone, Hirohito