Long term health-related quality of life in survivors of sepsis in South West Wales: an epidemiological study.
Long term health-related quality of life in survivors of sepsis in South West Wales: an epidemiological study.
复制标题
DOI：
10.1371/journal.pone.0116304
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Evans PA
中科院分区：
文献类型：
--
作者：
Battle CE;Davies G;Evans PA
脓毒症幸存者报告了出院后可能持续数年的持续问题。本研究的主要目的是调查 SIRS 和脓毒症幸存者的长期健康相关生活质量，并与威尔士规范数据进行比较，并控制年龄、住院时间和既往病史。第二个目的是调查长期健康相关生活质量的差异，特别是将患者分为三组； SIRS、单纯性败血症和严重败血症/败血性休克。采用前瞻性研究设计来调查所有就诊于急诊科或入住地区创伤中心重症监护室的脓毒症患者。收集基线人口统计数据、临床特征和结果，并在出院后六个月至两年内对幸存患者进行 SF-12v2 调查。与当地正常数据相比，所有患者的生活质量均显着下降（所有 p<0.0001）。在控制年龄、既往病史、住院时间和 ICU 住院时间时，与无并发症的脓毒症和 SIRS 患者相比，严重脓毒症/脓毒性休克患者的健康相关生活质量的身体成分下降更为明显。这是第一项专门针对不同 SIRS 和脓毒症患者群体以评估长期生活质量的观察性研究。用于比较的是当地人口标准，而不是无法反映一个国家人口复杂性的英国范围标准。
Survivors of sepsis report persistent problems that can last years after hospital discharge. The main aim of this study was to investigate long-term health-related quality of life in survivors of SIRS and sepsis compared with Welsh normative data, controlling for age, length of stay and pre-existing conditions. The second aim was to investigate any differences in long-term health-related quality of life specifically with the patients categorised into three groups; SIRS, uncomplicated sepsis and severe sepsis/septic shock. A prospective study design was used in order to investigate all sepsis patients either presenting to the Emergency Department or admitted to the Intensive Care Unit of a regional trauma centre. Baseline demographics, clinical characteristics and outcomes were collected and surviving patients were sent a SF-12v2 survey at between six months to two years post-hospital discharge. Quality of life was significantly reduced in all patients when compared to local normative data (all p<0.0001). Reductions in the physical components of health-related quality of life were more pronounced in severe sepsis/septic shock patients when compared to uncomplicated sepsis and SIRS patients, when controlling for age, pre-existing conditions, hospital and ICU length of stay. This is the first observational study to specifically focus on the different groups of SIRS and sepsis patients to assess long-term quality of life. Local population norms were used for comparison, rather than UK-wide norms that fail to reflect the intricacies of a country’s population.
登录
查看更多内容
幸存的败血症运动：严重败血症和化粪池冲击管理的国际指南，2012年。
影响因子：
38.9
作者：
Dellinger RP;Levy MM;Rhodes A;Annane D;Gerlach H;Opal SM;Sevransky JE;Sprung CL;Douglas IS;Jaeschke R;Osborn TM;Nunnally ME;Townsend SR;Reinhart K;Kleinpell RM;Angus DC;Deutschman CS;Machado FR;Rubenfeld GD;Webb S;Beale RJ;Vincent JL;Moreno R;Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
通讯作者：
Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
影响因子：
2.8
作者：
Parker, Scott L.;Godil, Saniya S.;McGirt, Matthew J.
通讯作者：
McGirt, Matthew J.
影响因子：
3.8
作者：
Hall, WH;Ramachandran, R;Vijayakumar, S
通讯作者：
Vijayakumar, S
影响因子：
8.8
作者：
Levy, MM;Fink, MP;Ramsay, G
通讯作者：
Ramsay, G
影响因子：
3.1
作者：
Daniels, Ron;Nutbeam, Tim;Galvin, Clare
通讯作者：
Galvin, Clare