RISC-target interaction: cleavage and translational suppression.
RISC-target interaction: cleavage and translational suppression.
复制标题
DOI：
10.1016/j.bbagrm.2008.07.005
复制
发表时间：
2008-11
影响因子：
4.7
通讯作者：
Han, Jiahuai
中科院分区：
文献类型：
--
作者：
van den Berg, Arjen;Mols, Johann;Han, Jiahuai
Small RNA molecules have been known and utilized to suppress gene expression for more than a decade. The discovery that these small RNA molecules are endogenously expressed in many organisms and have a critical role in controlling gene expression have led to the arising of a whole new field of research. Termed small interfering RNA (siRNA) or microRNA (miRNA) these ~22 nt RNA molecules have the capability to suppress gene expression through various mechanisms once they are incorporated in the multi-protein RNA-Induced Silencing Complex (RISC) and interact with their target mRNA. This review introduces siRNAs and microRNAs in a historical perspective and focuses on the key molecules in RISC, structural properties and mechanisms underlying the process of small RNA regulated post-transcriptional suppression of gene expression.
登录
查看更多内容
影响因子：
64.5
作者：
Foerstemann, Klaus;Horwich, Michael D.;Zamore, Phillip D.
通讯作者：
Zamore, Phillip D.
影响因子：
10.5
作者：
Caudy, AA;Myers, M;Hammond, SM
通讯作者：
Hammond, SM
影响因子：
3.7
作者：
Hua Z;Lv Q;Ye W;Wong CK;Cai G;Gu D;Ji Y;Zhao C;Wang J;Yang BB;Zhang Y
通讯作者：
Zhang Y
影响因子：
14.9
作者：
JACOB, CO;TASHMAN, NB
通讯作者：
TASHMAN, NB
影响因子：
5.3
作者：
Eulalio, Ana;Behm-Ansmant, Isabelle;Izaurralde, Elisa
通讯作者：
Izaurralde, Elisa