Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair.
Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair.
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DOI：
10.3389/fgene.2016.00213
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发表时间：
2016
影响因子：
3.7
通讯作者：
Mobasheri A
中科院分区：
文献类型：
--
作者：
Fellows CR;Matta C;Zakany R;Khan IM;Mobasheri A
目前基于细胞的修复策略已被证明不成功治疗软骨缺损和骨关节炎病变，因此需要在创新疗法方面取得进展，基于间充质干细胞（MSC）的疗法是一个不断扩大的研究领域。骨髓间充质干细胞能够分化成多种细胞谱系，并发挥旁分泌作用。由于其易于分离，扩增和低免疫原性，MSC是关节修复再生医学的一个有吸引力的选择。最近的研究已经确定了几种MSC组织储库，包括脂肪组织、骨髓、软骨、骨膜和肌肉。从这些离散的组织龛分离的MSC表现出不同的生物活性，并具有增强的再生潜力，为不同的组织类型。每种MSC类型对于软骨修复都有优点和缺点，它们在临床环境中的使用是权宜之计和有效性之间的平衡。在这篇综述中，我们探讨了与软骨修复和再生相关的挑战，使用MSC为基础的细胞疗法，并提供了一个概述的表型，生物活性和功能特性的MSC人口。本文还专门探讨了每种类型MSC的治疗潜力，特别关注哪些细胞能够产生分层透明样关节软骨再生。最后，我们强调了未来调查的领域。鉴于患者存在各种问题，软骨再生不太可能是简单的“一刀切”，而更可能是一系列需要系统应用以实现生物力学能力修复组织再生的解决方案。
Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion, and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum, and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities, and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple “one size fits all,” but more likely an array of solutions that need to be applied systematically to achieve regeneration of a biomechanically competent repair tissue.
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影响因子：
3.3
作者：
Adams, A. M.;Arruda, E. M.;Larkin, L. M.
通讯作者：
Larkin, L. M.
DOI：
10.1016/s1357-2725(02)00301-1
发表时间：
2003-04-01
影响因子：
4
作者：
Archer, CW;Francis-West, P
通讯作者：
Francis-West, P
影响因子：
--
作者：
Barbero, A;Ploegert, S;Martin, I
通讯作者：
Martin, I
影响因子：
4.2
作者：
Ball, Michael D.;Bonzani, Ian C.;Stevens, Molly M.
通讯作者：
Stevens, Molly M.
DOI：
10.1097/01.blo.0000145990.58146.3d
发表时间：
2005-01-01
影响因子：
4.2
作者：
Braman, JP;Bruckner, JD;Chansky, HA
通讯作者：
Chansky, HA