Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features.
Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features.
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DOI：
10.1371/journal.pone.0056130
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chien MH
中科院分区：
文献类型：
--
作者：
Cheng CW;Su JL;Lin CW;Su CW;Shih CH;Yang SF;Chien MH
核因子（NF）-κB的组成性激活在肝细胞癌（HCC）中是常见的。本研究检测了编码NF-κB1的NF KB 1和编码IκBα的NF KBIA启动子区域内的多态性与HCC发生的易感性和肿瘤的临床病理特征的关系。采用实时荧光定量聚合酶链反应（PCR）技术检测135例HCC患者和520例健康对照者的NFKB 1和NFKBIA基因多态性。NFKB 1 - 94 Ins基因多态性在HCC患者中的基因型频率显著高于对照组（校正比值比（AOR）= 2.23，95%可信区间（CI）1.32 ~ 3.77）。 NFKBIA −-519 C/T、-826 C/T或-881 A/G基因型和单倍型多态性在HCC患者和对照组之间的分布频率无统计学意义。此外，携带NFKB 1 - 94 Ins多态性的女性HCC患者与较低的临床分期和较小的肿瘤大小相关。我们的研究结果表明NFKB 1 - 94 Ins启动子多态性增加了女性HCC的风险，并可作为女性HCC患者临床分期和肿瘤大小的预测因子。
Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the susceptibility of developing HCC and clinicopathological characteristics of the tumors. Genetic polymorphisms of NFKB1 and NFKBIA were analyzed by a real-time polymerase chain reaction (PCR) in 135 HCC patients and 520 healthy controls. The genotypic frequency of the NFKB1 -94 Ins polymorphism in HCC patients was significantly higher than that of the controls (adjusted odds ratio (AOR) = 2.23; 95% confidence interval (CI) 1.32∼3.77). No statistical significance was observed for the distribution frequency of the NFKBIA −-519 C/T, -826 C/T, or -881 A/G genotype and haplotype polymorphisms between HCC patients and controls. Furthermore, female HCC patients carrying the NFKB1 -94 Ins polymorphism were associated with lower clinical stages and smaller tumor sizes. Our results indicate that the NFKB1 -94 Ins promoter polymorphism increased the risk of HCC, and may be applied as a predictive factor for the clinical stage and tumor size in female HCC patients.
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影响因子：
25.7
作者：
Liu, P;Kimmoun, E;Bernuau, D
通讯作者：
Bernuau, D
影响因子：
9.7
作者：
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通讯作者：
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作者：
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作者：
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作者：
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