Targeting and Insertion of Membrane Proteins in Mitochondria.
Targeting and Insertion of Membrane Proteins in Mitochondria.
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DOI：
10.3389/fcell.2021.803205
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发表时间：
2021
影响因子：
5.5
通讯作者：
Tokatlidis K
中科院分区：
文献类型：
--
作者：
Eaglesfield R;Tokatlidis K
线粒体膜蛋白在所有主要的线粒体功能中起着至关重要的作用。内膜的呼吸复合体是产生能量的关键。用于将必需代谢物流入/流出基质的载体蛋白。许多其他内膜蛋白在核编码蛋白（约占所有线粒体蛋白的99%）的输入和加工中发挥关键作用。外膜为核编码的蛋白质易位提供了另一个屏障，并且是参与输入过程、维持离子平衡以及外膜组件组装的许多蛋白质的所在地。虽然已经阐明了线粒体膜蛋白的输入和组装途径的许多方面，但仍然存在许多悬而未决的问题，特别是围绕呼吸复合物的组装，其中某些高度疏水的亚基由线粒体DNA编码并合成并从基质侧插入膜中。这篇综述将研究内部和外部线粒体膜蛋白的各种组装途径，同时讨论最新的结构和生化数据检查的生物合成过程。
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the generation of energy. The carrier proteins for the influx/efflux of essential metabolites to/from the matrix. Many other inner membrane proteins play critical roles in the import and processing of nuclear encoded proteins (∼99% of all mitochondrial proteins). The outer membrane provides another lipidic barrier to nuclear-encoded protein translocation and is home to many proteins involved in the import process, maintenance of ionic balance, as well as the assembly of outer membrane components. While many aspects of the import and assembly pathways of mitochondrial membrane proteins have been elucidated, many open questions remain, especially surrounding the assembly of the respiratory complexes where certain highly hydrophobic subunits are encoded by the mitochondrial DNA and synthesised and inserted into the membrane from the matrix side. This review will examine the various assembly pathways for inner and outer mitochondrial membrane proteins while discussing the most recent structural and biochemical data examining the biogenesis process.
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DOI：
10.1073/pnas.2017636118
发表时间：
2021-01-05
影响因子：
11.1
作者：
Asseck LY;Mehlhorn DG;Monroy JR;Ricardi MM;Breuninger H;Wallmeroth N;Berendzen KW;Nowrousian M;Xing S;Schwappach B;Bayer M;Grefen C
通讯作者：
Grefen C
影响因子：
5.8
作者：
Eaglesfield R;Madsen MA;Sanyal S;Reboud J;Amtmann A
通讯作者：
Amtmann A
影响因子：
11.4
作者：
Bolliger, L;Junne, T;Lithgow, T
通讯作者：
Lithgow, T
影响因子：
7.8
作者：
Becker, Thomas;Wenz, Lena-Sophie;Pfanner, Nikolaus
通讯作者：
Pfanner, Nikolaus
影响因子：
16.6
作者：
Diederichs, Kathryn A.;Ni, Xiaodan;Buchanan, Susan K.
通讯作者：
Buchanan, Susan K.