Altered resting brain connectivity in persistent cancer related fatigue.
Altered resting brain connectivity in persistent cancer related fatigue.
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DOI：
10.1016/j.nicl.2015.04.022
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发表时间：
2015
影响因子：
4.2
通讯作者：
Harris, Richard E.
中科院分区：
文献类型：
--
作者：
Hampson, Johnson P.;Zick, Suzanna M.;Khabir, Tohfa;Wright, Benjamin D.;Harris, Richard E.
关键词：
据估计，美国有300万女性作为乳腺癌幸存者生活，持续性癌症相关疲劳（PCRF）破坏了这些女性中约30%的生活。PCRF与生活质量下降、睡眠质量下降、认知受损和抑郁症有关。癌症相关疲劳的机制尚未得到很好的理解;然而，初步研究结果表明，大脑中的功能障碍活动是一个潜在的因素。在这里，我们调查的内在静息状态连接在这个人群中的PCRF之间的关系。23名年龄匹配的乳腺癌幸存者（15名疲劳和8名非疲劳）在研究前至少12周完成了所有癌症相关治疗，被招募进行功能连接磁共振成像（fcMRI）。内在的静息状态网络进行了检查与种子为基础的和独立的成分分析方法。比较了各组之间的大脑连接模式以及与自我报告的疲劳症状的相关性。疲劳组患者左顶下小叶与额上级回的连通性显著高于非疲劳组（P <0.05）。在疲劳组中，这种增强的连接性与身体疲劳增加（P = 0.04，r = 0.52）和睡眠质量差（P = 0.04，r = 0.52）相关。相比之下，非疲劳组的右侧楔前叶与导水管周围灰质以及左侧IPL与膝下皮质之间的连通性更大（P <0.05 FDR校正）。在疲劳受试者中，精神疲劳评分与更大的默认模式网络（DMN）连接到上级额回（P = 0.05 FDR校正）相关（r = 0.82），而非疲劳组的连接较少（r =-0.88）。这些发现表明，有增强的内在DMN连接额回乳腺癌幸存者持续疲劳。由于DMN是一个参与自我参照思维的网络，我们推测DMN和额回之间的连接增强可能与精神疲劳和睡眠质量差有关。相比之下，增强的DMN和区域之间的连接，在膝下扣带和脑干可能在非疲劳组的保护功能。第一项将自我报告的疲劳与内在大脑连接联系起来的癌症研究疲劳和非疲劳组显示出不同的上级额叶连接。连接水平与自我报告的疲劳和睡眠质量相关。
There is an estimated 3 million women in the US living as breast cancer survivors and persistent cancer related fatigue (PCRF) disrupts the lives of an estimated 30% of these women. PCRF is associated with decreased quality of life, decreased sleep quality, impaired cognition and depression. The mechanisms of cancer related fatigue are not well understood; however, preliminary findings indicate dysfunctional activity in the brain as a potential factor. Here we investigate the relationship between PCRF on intrinsic resting state connectivity in this population. Twenty-three age matched breast cancer survivors (15 fatigued and 8 non-fatigued) who completed all cancer-related treatments at least 12 weeks prior to the study, were recruited to undergo functional connectivity magnetic resonance imaging (fcMRI). Intrinsic resting state networks were examined with both seed based and independent component analysis methods. Comparisons of brain connectivity patterns between groups as well as correlations with self-reported fatigue symptoms were performed. Fatigued patients displayed greater left inferior parietal lobule to superior frontal gyrus connectivity as compared to non-fatigued patients (P < 0.05 FDR corrected). This enhanced connectivity was associated with increased physical fatigue (P = 0.04, r = 0.52) and poor sleep quality (P = 0.04, r = 0.52) in the fatigued group. In contrast greater connectivity in the non-fatigued group was found between the right precuneus to the periaqueductal gray as well as the left IPL to subgenual cortex (P < 0.05 FDR corrected). Mental fatigue scores were associated with greater default mode network (DMN) connectivity to the superior frontal gyrus (P = 0.05 FDR corrected) among fatigued subjects (r = 0.82) and less connectivity in the non-fatigued group (r = −0.88). These findings indicate that there is enhanced intrinsic DMN connectivity to the frontal gyrus in breast cancer survivors with persistent fatigue. As the DMN is a network involved in self-referential thinking we speculate that enhanced connectivity between the DMN and the frontal gyrus may be related to mental fatigue and poor sleep quality. In contrast, enhanced connectivity between the DMN and regions in the subgenual cingulate and brainstem may serve a protective function in the non-fatigued group. First cancer study to link self-reported fatigue to intrinsic brain connectivity Fatigue and non-fatigue groups showed differential superior frontal connectivity. Level of connectivity was correlated with self-reports of fatigue and sleep-quality.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Murphy, Kevin;Birn, Rasmus M.;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1073/pnas.1312902110
发表时间：
2013-11-12
影响因子：
11.1
作者：
Kucyi, Aaron;Salomons, Tim V.;Davis, Karen D.
通讯作者：
Davis, Karen D.
影响因子：
2.5
作者：
Calhoun, VD;Adali, T;Pekar, JJ
通讯作者：
Pekar, JJ