Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist.
Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist.
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DOI：
10.1016/j.biopsych.2008.09.029
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发表时间：
2009-01-15
影响因子：
10.6
通讯作者：
Zarate, Carlos A., Jr.
中科院分区：
文献类型：
--
作者：
Phelps, Laura E.;Brutsche, Nancy;Moral, Jazmin R.;Luckenbaugh, David A.;Manji, Husseini K.;Zarate, Carlos A., Jr.
情绪障碍和酒精依赖之间存在很高的共病率。此外，氯胺酮（一种最近描述的具有快速起效抗抑郁作用的解离麻醉剂）和乙醇都是 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。先前对有酒精依赖家族史的健康人的调查发现，这些人对氯胺酮的知觉障碍和烦躁反应的反应减弱，与有自我报告的酒精依赖史的人相似。这项研究调查了酒精依赖家族史是否影响氯胺酮的初始抗抑郁作用。 26 名患有 DSM-IV 难治性重度抑郁症的受试者接受了开放式静脉输注盐酸氯胺酮 (0.5 mg/kg)，并在基线、输注后 40、80、120 和 230 分钟时使用各种抑郁量表进行评分。主要结果指标是蒙哥马利-阿斯伯格抑郁评定量表（MADRS）分数。与没有酒精依赖家族史的受试者相比，有酒精依赖家族史的受试者的 MADRS 评分显着改善。酒精依赖家族史似乎预示着对 NMDA 受体拮抗剂的快速初始抗抑郁反应。
A high rate of comorbidity exists between mood disorders and alcohol dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently described rapid-onset antidepressant effect, and ethanol are N-methyl-D-aspartate (NMDA) receptor antagonists. Previous investigations of healthy individuals with a family history of alcohol-dependence have found that these individuals have an attenuated response to ketamine's perceptual disturbance and dysphoric effects similar to that found in individuals with a self-reported history of alcohol dependence. This study investigated whether a family history of alcohol dependence influences ketamine's initial antidepressant effect. Twenty-six subjects with DSM-IV treatment-resistant major depression were given an open-label intravenous infusion of ketamine hydrochloride (0.5 mg/kg) and rated using various depression scales at baseline, 40, 80, 120, and 230 minutes post-infusion. The primary outcome measure was Montgomery-Asberg Depression Rating Scale (MADRS) scores. Subjects with a family history of alcohol dependence showed significantly greater improvement in MADRS scores compared with subjects who had no family history of alcohol dependence. A family history of alcohol dependence appears to predict a rapid initial antidepressant response to an NMDA receptor antagonist.
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影响因子：
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通讯作者：
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