Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta—Validation and Reference Values
Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta—Validation and Reference Values
复制标题
人体胸腹主动脉稳态多频磁共振弹性成像验证和参考值
DOI：
10.1097/rli.0000000000000654
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发表时间：
2020
影响因子：
6.7
通讯作者：
Elgeti T
中科院分区：
文献类型：
--
作者：
Schaafs LA;Schrank F;Warmuth C;Steffen IG;Braun J;Hamm B;Sack I;Elgeti T
目的本研究的目的是调查潜在的频闪波场采样为基础的多频磁共振弹性成像（sMRE）定量刚度的人胸腹主动脉在vivo.Materials和方法的sMRE的胸和腹主动脉进行了1.5 T场强在20名健康志愿者，年龄27至77岁（3例女性;中位年龄33岁;四分位距[IQR] 16岁）。在3个解剖区域：升胸主动脉（AA）、降胸主动脉（AD）和腹主动脉（AAb）的舒张期重建并评价剪切波速度（SWS）的复合图。SWS图由2名阅片员阅读。在sMRE前无创测定血压和脉搏波速度。数据以中位数（IQR）形式给出，并使用Kruskal-Wallis和Wilcoxon秩和检验进行比较。组内相关性用于确定观察者间和观察者内的一致性以及再现性。进行多元线性回归分析，以评估年龄，性别，血管直径，血压，脉搏波速度和主动脉段上测得的SWS.ResultsAll 20名参与者进行了成功的SMRE，导致在60个主动脉段的影响。AA、AD和AAb的中位SWS（IQR）分别为1.62（0.16）m/s、2.40（0.24）m/s和2.48（0.58）m/s。AA组SWS明显低于AAb组（P< 0.001），而AD组与AAb组SWS无显著性差异（P= 0.67）。观察者间和观察者内的一致性以及再现性非常好，组内相关系数在0.957和0.998之间。年龄对测量的SWS有显著但微弱的影响，从AA到AD和AAb（R2分别为0.229，0.275，0.377; P= 0.001-0.005）。我们的研究结果与已知的主动脉硬度差异在不同的解剖位置，并证明了潜在的sMRE的胸腹主动脉的临床刚度测量，这可能允许检测的生理变化和心血管疾病。
ObjectivesThe aim of this study was to investigate the potential of stroboscopic-wavefield-sampling-based multifrequency magnetic resonance elastography (sMRE) for quantifying the stiffness of the human thoracic and abdominal aorta in vivo.Materials and MethodsThe sMRE of the thoracic and abdominal aorta was performed at 1.5 T field strength in 20 healthy volunteers aged 27 to 77 years (3 women; median age, 33 years; interquartile range [IQR], 16 years). Compound maps of shear wave speed (SWS) were reconstructed and evaluated during the diastolic phase in 3 anatomical regions: ascending thoracic aorta (AA), descending thoracic aorta (AD), and abdominal aorta (AAb). The SWS maps were read by 2 readers. Blood pressure and pulse wave velocity were determined noninvasively before sMRE. Data are given as median (IQR) and were compared using the Kruskal-Wallis and Wilcoxon rank sum tests. Intraclass correlation was used to determine interobserver and intraobserver agreement, as well as reproducibility. Multiple linear regression analysis was performed to evaluate effects of age, sex, vessel diameter, blood pressure, pulse wave velocity, and aortic segment on measured SWS.ResultsAll 20 participants underwent successful sMRE, resulting in a total of 60 aortic segments. The median SWS (IQR) of AA, AD, and AAb was 1.62 (0.16) m/s, 2.40 (0.24) m/s, and 2.48 (0.58) m/s, respectively. The SWS in AA was significantly lower (P< 0.001), and no differences in SWS (P= 0.67) were found between AD and AAb. Interobserver and intraobserver agreement, as well as reproducibility, was excellent, with intraclass correlation coefficients ranging between 0.957 and 0.998. A significant but weak influence of age on measured SWS was found, which increased from AA to AD and AAb (R 2= 0.229, 0.275, 0.377, respectively; P= 0.001-0.005).ConclusionsQuantification of aortic stiffness in different segments of the human aorta is possible with sMRE. Our results correlate well with known aortic stiffness differences in different anatomical locations and demonstrate the potential of sMRE for clinical stiffness measurement of the thoracoabdominal aorta, which may allow detection of physiological variation and cardiovascular diseases.
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DOI：
10.1161/hypertensionaha.114.00921
发表时间：
2014-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Mitchell GF
通讯作者：
Mitchell GF
影响因子：
14
作者：
Hickson, Stacey S.;Butlin, Mark;Wilkinson, Ian B.
通讯作者：
Wilkinson, Ian B.
影响因子：
6.3
作者：
Schrank，Felix;Warmuth，Carsten;Sack，Ingolf
通讯作者：
Sack，Ingolf
DOI：
10.1016/s0735-1097(01)01504-2
发表时间：
2001-10-01
影响因子：
24
作者：
Rogers, WJ;Hu, YL;Reichek, N
通讯作者：
Reichek, N
影响因子：
3.3
作者：
Woodrum, D. A.;Romano, A. J.;Ehman, R. L.
通讯作者：
Ehman, R. L.